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Levels of oxylipins, endocannabinoids and related lipids in plasma before and after low-level exposure to acrolein in healthy individuals and individuals with chemical intolerance
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- Claeson, Anna-Sara, 1974- (author)
- Umeå universitet,Institutionen för psykologi
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- Gouveia-Figueira, Sandra (author)
- Umeå universitet,Kemiska institutionen
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- Häggström, Jenny (author)
- Umeå universitet,Statistik
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- Elsevier BV, 2017
- 2017
- English.
- In: Prostaglandins, Leukotrienes and Essential Fatty Acids. - : Elsevier BV. - 0952-3278 .- 1532-2823. ; 121, s. 60-67
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Oxylipins and endocannabinoids play important biological roles, including effects upon inflammation. It is not known whether the circulating levels of these lipids are affected by inhalation of the environmental pollutant acrolein. In the present study, we have investigated the consequences of low-level exposure to acrolein on oxylipin, endocannabinoid and related lipid levels in the plasma of healthy individuals and individuals with chemical intolerance (CI), an affliction with a suggested inflammatory origin. Participants were exposed twice (60 min) to heptane and a mixture of heptane and acrolein. Blood samples were collected before exposure, after and 24 h post-exposure. There were no overt effects of acrolein exposure on the oxylipin lipidome or endocannibinoids detectable in the bloodstream at the time points investigated. No relationship between basal levels or levels after exposure to acrolein and CI could be identified. This implicates a minor role of inflammatory mediators on the systemic level in CI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- Oxylipins
- Endocannabinoids
- Plasma
- Human exposure
- Acrolein
- Chemical intolerance
Publication and Content Type
- ref (subject category)
- art (subject category)
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