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An altered immune r...
An altered immune response to Epstein-Barr virus in multiple sclerosis : a prospective study
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- Sundström, P (author)
- Umeå universitet,Neurologi
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- Juto, Per (author)
- Umeå universitet,Virologi
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- Wadell, G (author)
- Umeå universitet,Virologi
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning
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- Svenningsson, A (author)
- Umeå universitet,Neurologi
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- Nyström, Lennarth (author)
- Umeå universitet,Epidemiologi och folkhälsovetenskap
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- Dillner, Joakim (author)
- Karolinska Institutet,Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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- Forsgren, L (author)
- Umeå universitet,Neurologi
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(creator_code:org_t)
- Aan publication, 2004
- 2004
- English.
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In: Neurology. - : Aan publication. - 0028-3878 .- 1526-632X. ; 62:12, s. 2277-82
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Objective: To investigate the association between human herpesviruses and multiple sclerosis (MS), as well as between measles virus and MS.Methods: The authors identified prospectively collected serum samples from 73 MS cases and retrospective sera from 161 MS cases in two population-based serum bank registers. Analyses of IgG antibody responses in cases and matched referents were performed for Epstein-Barr virus (EBV [EBNA-1 and VCA]), human herpesvirus 6 (HHV-6), herpes simplex virus (HSV), varicella zoster virus (VZV), and measles.Results: All cases showed signs of past EBV infection. High activity to EBNA-1 and HHV-6 significantly (borderline significance for HHV-6) increased the risk for MS in prospective sera. A discrepancy between activities to EBNA-1 and VCA was striking in MS samples collected less than 5 years before relapsing-remitting MS onset, where high activity to EBNA-1 significantly increased, and high VCA activity significantly decreased the risk for MS. There was no support for major causal roles for HSV, VZV, or measles.Conclusion: Individuals who will develop MS exhibit an altered immune response against the EBV virus characterized by a high IgG activity to EBNA-1 in the absence of high activity to VCA, this being most pronounced in the 5-year period preceding MS onset.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Adolescent
- Adult
- Aged
- Antigens; Viral/immunology
- Capsid Proteins/immunology
- Epstein-Barr Virus Infections/*immunology
- Epstein-Barr Virus Nuclear Antigens/immunology
- Female
- Herpesvirus 4; Human/*immunology
- Humans
- Immunoglobulin G/immunology
- Male
- Middle Aged
- Multiple Sclerosis/*immunology/*virology
- Prospective Studies
- Retrospective Studies
Publication and Content Type
- ref (subject category)
- art (subject category)
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