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THAP1 :
THAP1 : role in mouse embryonic stem cell survival and differentiation
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- Aguilo, Francesca (author)
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA
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Zakirova, Zuchra (author)
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Nolan, Katie (author)
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Wagner, Ryan (author)
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Sharma, Rajal (author)
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Hogan, Megan (author)
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Wei, Chengguo (author)
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Sun, Yifei (author)
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Walsh, Martin J. (author)
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Kelley, Kevin (author)
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Zhang, Weijia (author)
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Ozelius, Laurie J. (author)
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Gonzalez-Alegre, Pedro (author)
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Zwaka, Thomas P. (author)
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Ehrlich, Michelle E. (author)
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(creator_code:org_t)
- Cell Press, 2017
- 2017
- English.
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In: Stem Cell Reports. - : Cell Press. - 2213-6711. ; 9:1, s. 92-107
- Related links:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- THAP1 (THAP [Thanatos-associated protein] domain-containing, apoptosis-associated protein 1) is a ubiquitously expressed member of a family of transcription factors with highly conserved DNA-binding and protein-interacting regions. Mutations in THAP1 cause dystonia, DYT6, a neurologic movement disorder. THAP1 downstream targets and the mechanism via which it causes dystonia are largely unknown. Here, we show that wild-type THAP1 regulates embryonic stem cell (ESC) potential, survival, and proliferation. Our findings identify THAP1 as an essential factor underlying mouse ESC survival and to some extent, differentiation, particularly neuroectodermal. Loss of THAP1 or replacement with a disease-causing mutation results in an enhanced rate of cell death, prolongs Nanog, Prdm14, and/or Rex1 expression upon differentiation, and results in failure to upregulate ectodermal genes. ChIP-Seq reveals that these activities are likely due in part to indirect regulation of gene expression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Utvecklingsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Developmental Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Aguilo, Francesc ...
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Zakirova, Zuchra
-
Nolan, Katie
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Wagner, Ryan
-
Sharma, Rajal
-
Hogan, Megan
-
show more...
-
Wei, Chengguo
-
Sun, Yifei
-
Walsh, Martin J.
-
Kelley, Kevin
-
Zhang, Weijia
-
Ozelius, Laurie ...
-
Gonzalez-Alegre, ...
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Zwaka, Thomas P.
-
Ehrlich, Michell ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Medical Biotechn ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Developmental Bi ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Stem Cell Report ...
- By the university
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Umeå University