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Androgen dependent ...
Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development
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- Metzler, Veronika M. (author)
- University of Nottingham
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- de Brot, Simone (author)
- University of Nottingham
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- Robinson, Robert S. (author)
- University of Nottingham
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- Jeyapalan, Jennie N. (author)
- University of Nottingham
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- Rakha, Emad (author)
- University of Nottingham
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- Walton, Thomas (author)
- Nottingham University Hospitals NHS Trust
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- Gardner, David S. (author)
- University of Nottingham
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- Lund, Emma F. (author)
- University of Nottingham
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- Whitchurch, Jonathan (author)
- University of Nottingham
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- Haigh, Daisy (author)
- University of Nottingham
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- Lochray, Jack M. (author)
- University of Nottingham
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Robinson, Brian D. (author)
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- Allegrucci, Cinzia (author)
- University of Nottingham
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- Fray, Rupert G. (author)
- University of Nottingham
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- Persson, Jenny L. (author)
- Umeå University,Lund University,Lunds universitet,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Translational Medicine, Lund University, Malmo, Sweden,Experimentell cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Experimental Cancer Research, Malmö,Lund University Research Groups
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- Odum, Niels (author)
- University of Copenhagen
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- Miftakhova, Regina R. (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Kazan Federal University, Kazan, Republic of Tatarstan, Russian Federation
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- Rizvanov, Albert A. (author)
- Kazan Federal University
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- Hughes, Ieuan A. (author)
- University of Cambridge
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- Tadokoro-Cuccaro, Rieko (author)
- University of Cambridge
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- Heery, David M. (author)
- University of Nottingham
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- Rutland, Catrin S. (author)
- University of Nottingham
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- Mongan, Nigel P. (author)
- University of Nottingham
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(creator_code:org_t)
- W B SAUNDERS CO LTD, 2017
- 2017
- English.
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In: Placenta. - : W B SAUNDERS CO LTD. - 0143-4004 .- 1532-3102. ; 56, s. 79-85
- Related links:
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https://nottingham-r...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- The placenta and tumors share important characteristics, including a requirement to establish effective angiogenesis. In the case of the placenta, optimal angiogenesis is required to sustain the blood flow required to maintain a successful pregnancy, whereas in tumors establishing new blood supplies is considered a key step in supporting metastases. Therefore the development of novel angiogenesis inhibitors has been an area of active research in oncology. A subset of the molecular processes regulating angiogenesis are well understood in the context of both early placentation and tumorigenesis. In this review we focus on the well-established role of androgen regulation of angiogenesis in cancer and relate these mechanisms to placental angiogenesis. The physiological actions of androgens are mediated by the androgen receptor (AR), a ligand dependent transcription factor. Androgens and the AR are essential for normal male embryonic development, puberty and lifelong health. Defects in androgen signalling are associated with a diverse range of clinical disorders in men and women including disorders of sex development (DSD), polycystic ovary syndrome in women and many cancers. We summarize the diverse molecular mechanisms of androgen regulation of angiogenesis and infer the potential significance of these pathways to normal and pathogenic placental function. Finally, we offer potential research applications of androgen-targeting molecules developed to treat cancer as investigative tools to help further delineate the role of androgen signalling in placental function and maternal and offspring health in animal models.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Nuclear receptor
- Epigenetics
- Angiogenesis
- VEGF
- Angiogenesis
- Epigenetics
- Nuclear receptor
- VEGF
Publication and Content Type
- ref (subject category)
- art (subject category)
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Placenta
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- By the author/editor
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Metzler, Veronik ...
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de Brot, Simone
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Robinson, Robert ...
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Jeyapalan, Jenni ...
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Rakha, Emad
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Walton, Thomas
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show more...
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Gardner, David S ...
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Lund, Emma F.
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Whitchurch, Jona ...
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Haigh, Daisy
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Lochray, Jack M.
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Robinson, Brian ...
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Allegrucci, Cinz ...
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Fray, Rupert G.
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Persson, Jenny L ...
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Odum, Niels
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Miftakhova, Regi ...
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Rizvanov, Albert ...
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Hughes, Ieuan A.
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Tadokoro-Cuccaro ...
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Heery, David M.
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Rutland, Catrin ...
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Mongan, Nigel P.
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- MEDICAL AND HEALTH SCIENCES
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- Articles in the publication
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Placenta
- By the university
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Umeå University
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Lund University