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Left atrial appenda...
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Nielsen-Kudsk, Jens Erik
(author)
Left atrial appendage occlusion versus standard medical care in patients with atrial fibrillation and intracerebral haemorrhage : a propensity score-matched follow-up study
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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EUROPA EDITION,2017
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-138237
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-138237URI
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https://doi.org/10.4244/EIJ-D-17-00201DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:136258726URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Aims: The aim of this study was to investigate the prognosis in patients with atrial fibrillation (AF) and intracerebral haemorrhage (ICH) having a left atrial appendage occlusion (LAAO) versus patients receiving standard medical therapy. Methods and results: A total of 151 patients from the Nordic countries with AF and previous ICH who underwent LAAO using the AMPLATZER Cardiac Plug or the AMPLATZER AMULET were compared to a propensity score-matched group of 151 patients receiving standard medical therapy. The two groups were matched so that their risks for stroke and bleeding were similar (CHA2DS2-VASc and HAS-BLED scores). The standard care patients were identified from the Danish Stroke Registry among 787 patients with AF and ICH. The primary endpoint was a composite of all-cause mortality, ischaemic stroke and major bleeding. Patients with AF and a prior ICH treated with LAAO had a lower risk of the composite outcome as compared to patients treated with standard medical care (events/1,000 years [95% confidence interval]: 53.3 [44.3-64.1] vs. 366.7 [298.2-450.9]; hazard ratio 0.16 [0.07-0.37]). Conclusions: LAAO is suggested to be of major clinical benefit in AF patients having sustained an ICH. These results have to be confirmed in a randomised clinical trial.
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Johnsen, Soren Paaske
(author)
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Wester, PerKarolinska Institutet,Umeå universitet,Medicin,Karolinska Inst, Danderyd, Sweden(Swepub:umu)pewe0002
(author)
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Damgaard, Dorte
(author)
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Airaksinen, Juhani
(author)
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Lund, Juha
(author)
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De Backer, Ole
(author)
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Pakarinen, Sami
(author)
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Odenstedt, Jacob
(author)
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Vikman, Saila
(author)
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Settergren, MagnusKarolinska Institutet
(author)
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Kongstad, Ole
(author)
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Rosenqvist, MartenKarolinska Institutet
(author)
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Krieger, Derk W.
(author)
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Umeå universitetMedicin
(creator_code:org_t)
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In:EuroIntervention: EUROPA EDITION13:3, s. 371-3781774-024X1969-6213
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Nielsen-Kudsk, J ...
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Johnsen, Soren P ...
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Wester, Per
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Damgaard, Dorte
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Airaksinen, Juha ...
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Lund, Juha
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De Backer, Ole
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Pakarinen, Sami
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Odenstedt, Jacob
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Vikman, Saila
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Kongstad, Ole
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Rosenqvist, Mart ...
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Krieger, Derk W.
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