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CCL11, a novel medi...
CCL11, a novel mediator of inflammatory bone resorption
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- Kindstedt, Elin, 1991- (author)
- Umeå universitet,Institutionen för odontologi
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- Koskinen Holm, Cecilia (author)
- Umeå universitet,Institutionen för odontologi
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- Sulniute, Rima (author)
- Umeå universitet,Institutionen för odontologi
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- Martinez-Carrasco, Irene (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik,Molekylär Infektionsmedicin, Sverige (MIMS)
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- Lundmark, Richard (author)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Institutionen för medicinsk kemi och biofysik,Molekylär Infektionsmedicin, Sverige (MIMS)
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- Lundberg, Pernilla (author)
- Umeå universitet,Institutionen för odontologi
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(creator_code:org_t)
- 2017-07-13
- 2017
- English.
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In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 7:1
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- Normal bone homeostasis, which is regulated by bone-resorbing osteoclasts and bone-forming osteoblasts is perturbed by inflammation. Inchronic inflammatory disease with disturbed bone remodelling, e.g. rheumatoid arthritis, patients show increased serum levels of the chemokine eotaxin-1 (CCL11). Herein, we demonstrate an inflammatory driven expression of CCL11 in bone tissue and a novel role of CCL11 in osteoclast migration and resorption. Using an inflammatory bone lesion model and primary cell cultures, we discovered that osteoblasts express CCL11 in vivo and in vitro and that expression increased during inflammatory conditions. Osteoclasts did not express CCL11, but the high affinity receptor CCR3 was significantly upregulated during osteoclast differentiation and found to colocalise with CCL11. Exogenous CCL11 was internalised in osteoclast and stimulated the migration of pre-osteoclast and concomitant increase in bone resorption. Our data pinpoints that the CCL11/CCR3 pathway could be a new target for treatment of inflammatory bone resorption.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- biology
- biologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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