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  • Kindstedt, ElinUmeå universitet,Institutionen för odontologi (author)

Marginal jawbone loss is associated with onset of rheumatoid arthritis and is related to plasma level of receptor activator of nuclear factor kappa-B-ligand (RANKL)

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  • LIBRIS-ID:oai:DiVA.org:umu-139691
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-139691URI

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  • Language:English
  • Summary in:English

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  • Subject category:vet swepub-contenttype
  • Subject category:ovr swepub-publicationtype

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  • OBJECTIVES: We investigated whether periodontitis, displayed as marginal jawbone loss, preceded onset of symptoms of RA. Furthermore, we analysed plasma levels of receptor activator of nuclear factor kappa-B (RANKL), a cytokine crucial for bone resorption and of anti-citrullinated peptide antibodies (ACPA) in pre-symptomatic individuals compared with controls.METHODS: Marginal jawbone levels were measured on dental radiographs from the premolar/molar regions of the jaws of 176 subjects of whom 93 had developed RA. Of these, 47 had documented radiographs predating symptom onset and for 45 of them sex, age and smoking status referents could be matched. The plasma RANKL concentrations were analysed using ELISA. The receiver operating characteristic curve was used to define the cut-off value.RESULTS: Compared with matched referents, bone loss was significantly higher in never-smoking, pre-symptomatic subjects and increasing levels of bone loss was associated with higher risk to develop subsequent RA (hazard ratio=1.06, 95%CI 1.01, 1.11). No association was found in smokers. In the pre- symptomatic RANKL-positive individuals a significantly higher extent of marginal jawbone loss, and those who were both RANKL- and ACPA positive displayed an even more pronounced jawbone loss.CONCLUSIONS: Marginal jawbone loss preceded clinical onset of symptoms of RA but the difference was only manifested in non-smokers. Moreover, pre- symptomatic RA-individuals, who were RANKL positive, displayed a significantly higher degree of marginal jawbone loss, particularly in ACPA positive individuals. 

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  • Johansson, LindaUmeå universitet,Institutionen för folkhälsa och klinisk medicin (author)
  • Palmqvist, PyUmeå universitet,Institutionen för odontologi (author)
  • Koskinen Holm, CeciliaUmeå universitet,Institutionen för odontologi (author)
  • Kokkonen, HeidiUmeå universitet,Institutionen för folkhälsa och klinisk medicin (author)
  • Johansson, IngegerdUmeå universitet,Institutionen för odontologi (author)
  • Rantapää Dahlqvist, SolbrittUmeå universitet,Institutionen för folkhälsa och klinisk medicin (author)
  • Lundberg, PernillaUmeå universitet,Institutionen för odontologi (author)
  • Umeå universitetInstitutionen för odontologi (creator_code:org_t)

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