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N-acylated derivati...
N-acylated derivatives of sulfamethoxazole block Chlamydia fatty acid synthesis and interact with FabF
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- Mojica, Sergio A. (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Salin, Olli (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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Bastidas, Robert J. (author)
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- Sunduru, Naresh (author)
- Umeå universitet,Kemiska institutionen
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- Hedenström, Mattias (author)
- Umeå universitet,Kemiska institutionen
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- Andersson, C. David (author)
- Umeå universitet,Kemiska institutionen
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- Núñez-Otero, Carlos (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Engström, Patrik (author)
- Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
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Valdivia, Raphael H. (author)
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- Elofsson, Mikael (author)
- Umeå universitet,Kemiska institutionen,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR)
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- Gylfe, Åsa (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR)
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(creator_code:org_t)
- American society for microbiology, 2017
- 2017
- English.
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In: Antimicrobial Agents and Chemotherapy. - : American society for microbiology. - 0066-4804 .- 1098-6596. ; 61:10
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The type II fatty acid synthesis (FASII) pathway is essential for bacterial lipid biosynthesis and continues to be a promising target for novel antibacterial compounds. Recently, it has been demonstrated that Chlamydia is capable of FASII and this pathway is indispensable for Chlamydia growth. Previously, a high-content screen with Chlamydia trachomatis-infected cells was performed, and acylated sulfonamides were identified to be potent growth inhibitors of the bacteria. C. trachomatis strains resistant to acylated sulfonamides were isolated by serial passage of a wild-type strain in the presence of low compound concentrations. Results from whole-genome sequencing of 10 isolates from two independent drug-resistant populations revealed that mutations that accumulated in fabF were predominant. Studies of the interaction between the FabF protein and small molecules showed that acylated sulfonamides directly bind to recombinant FabF in vitro and treatment of C. trachomatis-infected HeLa cells with the compounds leads to a decrease in the synthesis of Chlamydia fatty acids. This work demonstrates the importance of FASII for Chlamydia development and may lead to the development of new antimicrobials.
Subject headings
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Chlamydia trachomatis
- FAS
- antimicrobial agents
- drug targets
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Mojica, Sergio A ...
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Salin, Olli
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Bastidas, Robert ...
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Sunduru, Naresh
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Hedenström, Matt ...
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Andersson, C. Da ...
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show more...
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Núñez-Otero, Car ...
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Engström, Patrik
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Valdivia, Raphae ...
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Elofsson, Mikael
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Gylfe, Åsa
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
- Articles in the publication
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Antimicrobial Ag ...
- By the university
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Umeå University