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Decreased lipogenes...
Decreased lipogenesis-promoting factors in adipose tissue in postmenopausal women with overweight on a Paleolithic-type diet
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- Blomquist, Caroline (author)
- Umeå universitet,Medicin
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- Chorell, Elin (author)
- Umeå universitet,Medicin
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- Ryberg, Mats (author)
- Umeå universitet,Medicin
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- Mellberg, Caroline (author)
- Umeå universitet,Medicin
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- Worrsjö, Evelina (author)
- Umeå universitet,Fysiologisk kemi
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- Makoveichuk, Elena (author)
- Umeå universitet,Fysiologisk kemi
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- Larsson, Christel, 1972 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kost- och idrottsvetenskap,Department of Food and Nutrition, and Sport Science
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- Lindahl, Bernt (author)
- Umeå universitet,Yrkes- och miljömedicin
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- Olivecrona, Gunilla (author)
- Umeå universitet,Fysiologisk kemi
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- Olsson, Tommy (author)
- Umeå universitet,Medicin
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(creator_code:org_t)
- 2017-10-26
- 2018
- English.
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In: European Journal of Nutrition. - : Springer. - 1436-6207 .- 1436-6215. ; 57:8, s. 2877-2886
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Abstract
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- Purpose: We studied effects of diet-induced postmenopausal weight loss on gene expression and activity of proteins involved in lipogenesis and lipolysis in adipose tissue.Methods: Fifty-eight postmenopausal women with overweight (BMI 32.5 ± 5.5) were randomized to eat an ad libitum Paleolithic-type diet (PD) aiming for a high intake of protein and unsaturated fatty acids or a prudent control diet (CD) for 24 months. Anthropometry, plasma adipokines, gene expression of proteins involved in fat metabolism in subcutaneous adipose tissue (SAT) and lipoprotein lipase (LPL) activity and mass in SAT were measured at baseline and after 6 months. LPL mass and activity were also measured after 24 months.Results: The PD led to improved insulin sensitivity (P < 0.01) and decreased circulating triglycerides (P < 0.001), lipogenesis-related factors, including LPL mRNA (P < 0.05), mass (P < 0.01), and activity (P < 0.001); as well as gene expressions of CD36 (P < 0.05), fatty acid synthase, FAS (P < 0.001) and diglyceride acyltransferase 2, DGAT2 (P < 0.001). The LPL activity (P < 0.05) and gene expression of DGAT2 (P < 0.05) and FAS (P < 0.05) were significantly lowered in the PD group versus the CD group at 6 months and the LPL activity (P < 0.05) remained significantly lowered in the PD group compared to the CD group at 24 months.Conclusions: Compared to the CD, the PD led to a more pronounced reduction of lipogenesis-promoting factors in SAT among postmenopausal women with overweight. This could have mediated the favorable metabolic effects of the PD on triglyceride levels and insulin sensitivity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- LANTBRUKSVETENSKAPER -- Lantbruksvetenskap, skogsbruk och fiske -- Livsmedelsvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agriculture, Forestry and Fisheries -- Food Science (hsv//eng)
Keyword
- diet
- fat metabolism
- lipoprotein lipase
- obesity
- postmenopausal women
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Blomquist, Carol ...
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Chorell, Elin
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Ryberg, Mats
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Mellberg, Caroli ...
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Worrsjö, Evelina
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Makoveichuk, Ele ...
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show more...
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Larsson, Christe ...
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Lindahl, Bernt
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Olivecrona, Guni ...
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Olsson, Tommy
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Agriculture Fore ...
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and Food Science
- Articles in the publication
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European Journal ...
- By the university
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Umeå University
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University of Gothenburg