Search: onr:"swepub:oai:DiVA.org:umu-141977" >
Patients with high ...
Patients with high c-MYC-expressing squamous cell carcinomas of the tongue show better survival than those with low- and medium-expressing tumours
-
- Strindlund, Klas (author)
- Umeå universitet,Patologi
-
Troiano, Giuseppe (author)
-
Sgaramella, Nicola (author)
-
show more...
-
Coates, Philip J. (author)
-
- Gu, Xiaolian (author)
- Umeå universitet,Patologi
-
- Boldrup, Linda (author)
- Umeå universitet,Patologi
-
Califano, Luigi (author)
-
- Fåhraeus, Robin (author)
- Umeå universitet,Patologi,RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic; Institut de Génétique Moléculaire, Hôpital St. Louis, Université Paris 7, Paris, France
-
Muzio, Lorenzo Lo (author)
-
Ardito, Fatima (author)
-
Colella, Giuseppe (author)
-
Tartaro, Gianpaolo (author)
-
Franco, Renato (author)
-
- Norberg-Spaak, Lena (author)
- Umeå universitet,Öron- näs- och halssjukdomar
-
- Saadat, Mohammad (author)
- Umeå universitet,Öron- näs- och halssjukdomar
-
- Nylander, Karin (author)
- Umeå universitet,Patologi
-
show less...
-
(creator_code:org_t)
- 2017-05-09
- 2017
- English.
-
In: Journal of Oral Pathology & Medicine. - : John Wiley & Sons. - 0904-2512 .- 1600-0714. ; 46:10, s. 967-971
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Backgroundc-MYC is a potent oncoprotein with roles in a wide range of cellular processes such as differentiation, apoptosis and growth control. Deregulation of the MYC gene is commonly seen in human tumours resulting in overexpression of the protein. Here we studied expression of c-MYC in correlation to clinical outcome in patients with primary squamous cell carcinoma of the mobile tongue. MethodsImmunohistochemistry was used to identify c-MYC in a group of 104 tongue squamous cell carcinomas with an antibody directed against the N-terminal part of the protein. Staining was evaluated by multiplying the percentage of c-MYC-expressing cells with staining intensity, giving a quick score for each tumour. ResultsAll 104 tumours expressed c-MYC at varying levels. Quantitation according to per cent of positive cells and staining intensity revealed that most (15/21; 71%) high-expressing tumours were seen in males. Within the group of high c-MYC-expressing tumours, the majority were alive 2 and 5 years after treatment. ConclusionsThe present findings show that expression of c-MYC has prognostic value in squamous cell carcinoma of the tongue, and could be useful in choice of therapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- c-MYC
- radiotherapy
- squamous cell carcinoma
- tongue
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Strindlund, Klas
-
Troiano, Giusepp ...
-
Sgaramella, Nico ...
-
Coates, Philip J ...
-
Gu, Xiaolian
-
Boldrup, Linda
-
show more...
-
Califano, Luigi
-
Fåhraeus, Robin
-
Muzio, Lorenzo L ...
-
Ardito, Fatima
-
Colella, Giusepp ...
-
Tartaro, Gianpao ...
-
Franco, Renato
-
Norberg-Spaak, L ...
-
Saadat, Mohammad
-
Nylander, Karin
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Journal of Oral ...
- By the university
-
Umeå University