Search: onr:"swepub:oai:DiVA.org:umu-142388" > Circulating Folate,...
Fältnamn | Indikatorer | Metadata |
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000 | 05644naa a2200985 4500 | |
001 | oai:DiVA.org:umu-142388 | |
003 | SwePub | |
008 | 171129s2018 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1423882 URI |
024 | 7 | a https://doi.org/10.1093/jnci/djx1192 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Fanidi, Anouar4 aut |
245 | 1 0 | a Circulating Folate, Vitamin B6, and Methionine in Relation to Lung Cancer Risk in the Lung Cancer Cohort Consortium (LC3) |
264 | c 2017-07-22 | |
264 | 1 | b Oxford University Press,c 2018 |
338 | a print2 rdacarrier | |
520 | a Background: Circulating concentrations of B vitamins and factors related to one-carbon metabolism have been found to be strongly inversely associated with lung cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The extent to which these associations are present in other study populations is unknown.Methods: Within 20 prospective cohorts from the National Cancer Institute Cohort Consortium, a nested case-control study was designed including 5364 incident lung cancer case patients and 5364 control subjects who were individually matched to case patients by age, sex, cohort, and smoking status. Centralized biochemical analyses were performed to measure circulating concentrations of vitamin B6, folate, and methionine, as well as cotinine as an indicator of recent tobacco exposure. The association between these biomarkers and lung cancer risk was evaluated using conditional logistic regression models.Results: Participants with higher circulating concentrations of vitamin B6 and folate had a modestly decreased risk of lung cancer risk overall, the odds ratios when comparing the top and bottom fourths (OR 4vs1 ) being 0.88 (95% confidence interval [CI] = 0.78 to 1.00) and 0.86 (95% CI = 0.74 to 0.99), respectively. We found stronger associations among men (vitamin B6: OR 4vs1 = 0.74, 95% CI = 0.62 to 0.89; folate: OR 4vs1 = 0.75, 95% CI = 0.61 to 0.93) and ever smokers (vitamin B6: OR 4vs1 = 0.78, 95% CI = 0.67 to 0.91; folate: OR 4vs1 = 0.87, 95% CI = 0.73 to 1.03). We further noted that the association of folate was restricted to Europe/Australia and Asia, whereas no clear association was observed for the United States. Circulating concentrations of methionine were not associated with lung cancer risk overall or in important subgroups.Conclusions: Although confounding by tobacco exposure or reverse causation cannot be ruled out, these study results are compatible with a small decrease in lung cancer risk in ever smokers who avoid low concentrations of circulating folate and vitamin B6. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Muller, David C4 aut |
700 | 1 | a Yuan, Jian-Min4 aut |
700 | 1 | a Stevens, Victoria L4 aut |
700 | 1 | a Weinstein, Stephanie J4 aut |
700 | 1 | a Albanes, Demetrius4 aut |
700 | 1 | a Prentice, Ross4 aut |
700 | 1 | a Thomsen, Cynthia A4 aut |
700 | 1 | a Pettinger, Mary4 aut |
700 | 1 | a Cai, Qiuyin4 aut |
700 | 1 | a Blot, William J4 aut |
700 | 1 | a Wu, Jie4 aut |
700 | 1 | a Arslan, Alan A4 aut |
700 | 1 | a Zeleniuch-Jacquotte, Anne4 aut |
700 | 1 | a McCullough, Marjorie L4 aut |
700 | 1 | a Le Marchand, Loic4 aut |
700 | 1 | a Wilkens, Lynne R4 aut |
700 | 1 | a Haiman, Christopher A4 aut |
700 | 1 | a Zhang, Xuehong4 aut |
700 | 1 | a Han, Jiali4 aut |
700 | 1 | a Stampfer, Meir J4 aut |
700 | 1 | a Smith-Warner, Stephanie A4 aut |
700 | 1 | a Giovannucci, Edward4 aut |
700 | 1 | a Giles, Graham G4 aut |
700 | 1 | a Hodge, Allison M4 aut |
700 | 1 | a Severi, Gianluca4 aut |
700 | 1 | a Johansson, Mikaelu Umeå universitet,Onkologi4 aut0 (Swepub:umu)mijo0025 |
700 | 1 | a Grankvist, Kjellu Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)kjgr0002 |
700 | 1 | a Langhammer, Arnulf4 aut |
700 | 1 | a Krokstad, Steinar4 aut |
700 | 1 | a Næss, Marit4 aut |
700 | 1 | a Wang, Renwei4 aut |
700 | 1 | a Gao, Yu-Tang4 aut |
700 | 1 | a Butler, Lesley M4 aut |
700 | 1 | a Koh, Woon-Puay4 aut |
700 | 1 | a Shu, Xiao-Ou4 aut |
700 | 1 | a Xiang, Yong-Bing4 aut |
700 | 1 | a Li, Honglan4 aut |
700 | 1 | a Zheng, Wei4 aut |
700 | 1 | a Lan, Qing4 aut |
700 | 1 | a Visvanathan, Kala4 aut |
700 | 1 | a Bolton, Judith Hoffman4 aut |
700 | 1 | a Ueland, Per Magne4 aut |
700 | 1 | a Midttun, Øivind4 aut |
700 | 1 | a Ulvik, Arve4 aut |
700 | 1 | a Caporaso, Neil E4 aut |
700 | 1 | a Purdue, Mark4 aut |
700 | 1 | a Ziegler, Regina G4 aut |
700 | 1 | a Freedman, Neal D4 aut |
700 | 1 | a Buring, Julie E4 aut |
700 | 1 | a Lee, I-Min4 aut |
700 | 1 | a Sesso, Howard D4 aut |
700 | 1 | a Gaziano, J Michael4 aut |
700 | 1 | a Manjer, Jonas4 aut |
700 | 1 | a Ericson, Ulrika4 aut |
700 | 1 | a Relton, Caroline4 aut |
700 | 1 | a Brennan, Paul4 aut |
700 | 1 | a Johansson, Mattias4 aut |
710 | 2 | a Umeå universitetb Onkologi4 org |
773 | 0 | t Journal of the National Cancer Instituted : Oxford University Pressg 110:1q 110:1x 0027-8874x 1460-2105 |
856 | 4 | u https://academic.oup.com/jnci/article-pdf/110/1/57/25422471/djx119.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-142388 |
856 | 4 8 | u https://doi.org/10.1093/jnci/djx119 |
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