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Respiratory syncyti...
Respiratory syncytial virus in adults with severe acute respiratory illness in a high HIV prevalence setting
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Moyes, Jocelyn (author)
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Walaza, Sibongile (author)
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Pretorius, Marthi (author)
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Groome, Michelle (author)
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von Gottberg, Anne (author)
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Wolter, Nicole (author)
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Haffejee, Sumayya (author)
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Variava, Ebrahim (author)
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Cohen, Adam L. (author)
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Tempia, Stefano (author)
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- Kahn, Kathleen (author)
- Umeå universitet,Epidemiologi och global hälsa,MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; INDEPTH Network Accra, Ghana
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Dawood, Halima (author)
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Venter, Marietjie (author)
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Cohen, Cheryl (author)
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Madhi, Shabir A. (author)
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(creator_code:org_t)
- Saunders Elsevier, 2017
- 2017
- English.
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In: Journal of Infection. - : Saunders Elsevier. - 0163-4453 .- 1532-2742. ; 75:4, s. 346-355
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: There are limited data on the epidemiology of respiratory syncytial virus (RSV) illness in HIV-infected adults or the elderly in Africa. We studied the epidemiology of RSV-associated severe acute respiratory illness (SARI) hospitalizations in adults in South Africa from 2009 through 2013. Methods: Individuals admitted to sentinel surveillance hospitals were investigated by respiratory tract swabs for RSV, using a multiplex real-time polymerase chain reaction assay. The incidence of RSV-associated SARI was calculated for the one site with population denominators. Results: Of 7796 participants investigated, 329 (4%) tested positive for RSV. On multivariable analysis, HIV-infected individuals with RSV-associated SARI had greater odds of being in the age groups 18-44 and 45-64 years (odd ratios (OR) 26.3; 95% confidence interval (CI) 6.2-112.1 and OR 11.4; 95% CI 2.6-50.0) compared with those >= 65 years and being female (OR 2.7; 95% CI 1.4-5.4). The relative risk of hospitalization with RSV-associated SARI was 12-18 times higher in HIV infected individual compared to that of HIV-uninfected. Conclusion: The incidence of RSV-associated SARI was higher in HIV-infected individuals and those aged 65 years and older. Further studies are warranted to describe the disease association of RSV detected in adults with SARI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Respiratory syncytial virus
- HIV
- South Africa
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Moyes, Jocelyn
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Walaza, Sibongil ...
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Pretorius, Marth ...
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Groome, Michelle
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von Gottberg, An ...
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Wolter, Nicole
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show more...
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Haffejee, Sumayy ...
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Variava, Ebrahim
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Cohen, Adam L.
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Tempia, Stefano
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Kahn, Kathleen
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Dawood, Halima
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Venter, Marietji ...
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Cohen, Cheryl
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Madhi, Shabir A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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Journal of Infec ...
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Umeå University