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Respiratory syncyti...
Respiratory syncytial virus in adults with severe acute respiratory illness in a high HIV prevalence setting
- Article/chapterEnglish2017
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Saunders Elsevier,2017
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LIBRIS-ID:oai:DiVA.org:umu-142474
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-142474URI
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https://doi.org/10.1016/j.jinf.2017.06.007DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Background: There are limited data on the epidemiology of respiratory syncytial virus (RSV) illness in HIV-infected adults or the elderly in Africa. We studied the epidemiology of RSV-associated severe acute respiratory illness (SARI) hospitalizations in adults in South Africa from 2009 through 2013. Methods: Individuals admitted to sentinel surveillance hospitals were investigated by respiratory tract swabs for RSV, using a multiplex real-time polymerase chain reaction assay. The incidence of RSV-associated SARI was calculated for the one site with population denominators. Results: Of 7796 participants investigated, 329 (4%) tested positive for RSV. On multivariable analysis, HIV-infected individuals with RSV-associated SARI had greater odds of being in the age groups 18-44 and 45-64 years (odd ratios (OR) 26.3; 95% confidence interval (CI) 6.2-112.1 and OR 11.4; 95% CI 2.6-50.0) compared with those >= 65 years and being female (OR 2.7; 95% CI 1.4-5.4). The relative risk of hospitalization with RSV-associated SARI was 12-18 times higher in HIV infected individual compared to that of HIV-uninfected. Conclusion: The incidence of RSV-associated SARI was higher in HIV-infected individuals and those aged 65 years and older. Further studies are warranted to describe the disease association of RSV detected in adults with SARI.
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Walaza, Sibongile
(author)
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Pretorius, Marthi
(author)
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Groome, Michelle
(author)
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von Gottberg, Anne
(author)
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Wolter, Nicole
(author)
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Haffejee, Sumayya
(author)
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Variava, Ebrahim
(author)
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Cohen, Adam L.
(author)
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Tempia, Stefano
(author)
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Kahn, KathleenUmeå universitet,Epidemiologi och global hälsa,MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; INDEPTH Network Accra, Ghana(Swepub:umu)kaka0045
(author)
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Dawood, Halima
(author)
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Venter, Marietjie
(author)
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Cohen, Cheryl
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Madhi, Shabir A.
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Umeå universitetEpidemiologi och global hälsa
(creator_code:org_t)
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In:Journal of Infection: Saunders Elsevier75:4, s. 346-3550163-44531532-2742
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Moyes, Jocelyn
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Walaza, Sibongil ...
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Pretorius, Marth ...
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Groome, Michelle
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von Gottberg, An ...
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Wolter, Nicole
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Haffejee, Sumayy ...
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Variava, Ebrahim
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Cohen, Adam L.
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Tempia, Stefano
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Kahn, Kathleen
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Dawood, Halima
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Venter, Marietji ...
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Cohen, Cheryl
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Madhi, Shabir A.
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Journal of Infec ...
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Umeå University