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Anticancer effects ...
Anticancer effects of a plant lignan 7-hydroxymatairesinol on a prostate cancer model in vivo.
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- Bylund, Annika (author)
- Umeå universitet,Geriatrik
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Saarinen, Niina (author)
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- Zhang, Jie-Xian (author)
- Umeå universitet,Näringsforskning
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- Bergh, Anders (author)
- Umeå universitet,Patologi
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- Widmark, Anders (author)
- Umeå universitet,Onkologi
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- Johansson, Anders (author)
- Umeå universitet,Parodontologi
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- Lundin, Eva (author)
- Umeå universitet,Patologi
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Adlercreutz, Herman (author)
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning
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- Stattin, Pär (author)
- Umeå universitet,Urologi och andrologi
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Mäkelä, Sari (author)
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(creator_code:org_t)
- 2005
- 2005
- English.
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In: Experimental biology and medicine. - 1535-3702 .- 1535-3699. ; 230:3, s. 217-223
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Abstract
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- Clinical intervention studies and experimental studies with lignan-rich diets suggest that lignans may have inhibitory effects on prostate cancer, but no clinical or experimental studies with purified lignans have been published. The purpose of this study was to investigate the effect of a plant lignan 7-hydroxymatairesinol (HMR) on LNCaP human prostate cancer xenografts in athymic mice. Athymic nude male mice were injected subcutaneously with LNCaP cells. Starting 3 days after tumor cell injections, a control diet or a control diet supplemented with 0.15% or 0.30% of HMR was administered to mice and the tumor take rate and growth was observed for 9 weeks. HMR diet inhibited the growth of LNCaP tumors. Mice treated with HMR had smaller tumor volume, lower tumor take rate, increased proportion of nongrowing tumors, and higher tumor cell apoptotic index compared with controls. Furthermore, the cell proliferation index was reduced in mice receiving the 0.30% HMR diet compared with mice receiving the control diet. Our results suggest that dietary HMR started at the early phase of the tumor development inhibits the growth of the LNCaP human prostate cancer xenografts in athymic male mice.
Keyword
- Phytoestrogens
- 7-hydroxymatairesinol
- diet
- LNCaP human prostate adenocarcinoma
- athymic nude mice
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bylund, Annika
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Saarinen, Niina
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Zhang, Jie-Xian
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Bergh, Anders
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Widmark, Anders
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Johansson, Ander ...
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show more...
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Lundin, Eva
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Adlercreutz, Her ...
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Hallmans, Göran
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Stattin, Pär
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Mäkelä, Sari
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show less...
- Articles in the publication
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Experimental bio ...
- By the university
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Umeå University