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From COPD epidemiol...
From COPD epidemiology to studies of pathophysiological disease mechanisms : challenges with regard to study design and recruitment process
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- Lindberg, Anne (author)
- Umeå universitet,Medicin,Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå
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- Linder, Robert (author)
- Umeå universitet,Medicin,Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå
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- Backman, Helena (author)
- Umeå universitet,Yrkes- och miljömedicin,Department of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine, Umeå University, Umeå
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- Eriksson Ström, Jonas (author)
- Umeå universitet,Medicin,Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå
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- Frølich, Andreas (author)
- Umeå universitet,Medicin,Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå
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- Nilsson, Ulf, 1974- (author)
- Umeå universitet,Medicin,OLIN-studierna,Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå
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- Rönmark, Eva (author)
- Umeå universitet,Yrkes- och miljömedicin,Department of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine, Umeå University, Umeå
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- Johansson Strandkvist, Viktor (author)
- Luleå tekniska universitet,Hälsa och rehabilitering
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- Behndig, Annelie F (author)
- Umeå universitet,Medicin,Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå
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- Blomberg, Anders (author)
- Umeå universitet,Medicin,Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå
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(creator_code:org_t)
- 2017-12-17
- 2017
- English.
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In: European Clinical Respiratory Journal. - : Taylor & Francis. - 2001-8525. ; 4
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Abstract
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- Background: Chronic obstructive pulmonary disease (COPD) is a largely underdiagnosed disease including several phenotypes. In this report, the design of a study intending to evaluate the pathophysiological mechanism in COPD in relation to the specific phenotypes non-rapid and rapid decline in lung function is described together with the recruitment process of the study population derived from a population based study.Method: The OLIN COPD study includes a population-based COPD cohort and referents without COPD identified in 2002–04 (n = 1986), and thereafter followed annually since 2005. Lung function decline was estimated from baseline in 2002–2004 to 2010 (first recruitment phase) or to 2012/2013 (second recruitment phase). Individuals who met the predefined criteria for the following four groups were identified; group A) COPD grade 2–3 with rapid decline in FEV1 and group B) COPD grade 2–3 without rapid decline in FEV1 (≥60 and ≤30 ml/year, respectively), group C) ever-smokers, and group D) non-smokers with normal lung function. Groups A–C included ever-smokers with >10 pack years. The intention was to recruit 15 subjects in each of the groups A-D.Results: From the database groups A–D were identified; group A n = 37, group B n = 29, group C n = 41, and group D n = 55. Fifteen subjects were recruited from groups C and D, while this goal was not reached in the groups A (n = 12) and B (n = 10). The most common reasons for excluding individuals identified as A or B were comorbidities contraindicating bronchoscopy, or inflammatory diseases/immune suppressive medication expected to affect the outcome.Conclusion: The study is expected to generate important results regarding pathophysiological mechanisms associated with rate of decline in lung function among subjects with COPD and the in-detail described recruitment process, including reasons for non-participation, is a strength when interpreting the results in forthcoming studies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Sjukgymnastik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Physiotherapy (hsv//eng)
Keyword
- Chronic obstructive pulmonary disease
- disease mechanisms
- lung function decline
- smoking habits
- lungmedicin
- Lung Medicine
- epidemiologi
- Epidemiology
- Physiotherapy
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lindberg, Anne
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Linder, Robert
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Backman, Helena
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Eriksson Ström, ...
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Frølich, Andreas
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Nilsson, Ulf, 19 ...
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Rönmark, Eva
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Johansson Strand ...
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Behndig, Annelie ...
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Blomberg, Anders
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Physiotherapy
- Articles in the publication
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European Clinica ...
- By the university
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Umeå University
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Luleå University of Technology