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  • van Duijnhoven, Fraenzel J. B. (author)

Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2017-11-22
  • WILEY,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-144331
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-144331URI
  • https://doi.org/10.1002/ijc.31146DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:137431930URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-TrOndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n=626; HUNT2 n=112; median follow-up=6.9 years) were matched to 738 controls. Vitamin D [25(OH)D-2 and 25(OH)D-3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of 25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend=0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend=0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.

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  • Jenab, Mazda (author)
  • Hveem, Kristian (author)
  • Siersema, Peter D. (author)
  • Fedirko, Veronika (author)
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  • Halfweeg, Anouk (author)
  • van Kranen, Henk J. (author)
  • van den Ouweland, Jody M. W. (author)
  • Weiderpass, ElisabeteKarolinska Institutet (author)
  • Murphy, Neil (author)
  • Langhammer, Arnulf (author)
  • Ness-Jensen, EivindKarolinska Institutet (author)
  • Olsen, Anja (author)
  • Tjonneland, Anne (author)
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  • Peeters, Petra (author)
  • Brustad, Magritt (author)
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  • Chirlaque, Maria-Dolores (author)
  • Barricarte, Aurelio (author)
  • Manjer, Jonas (author)
  • Almquist, Martin (author)
  • Renström, FridaGenetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden(Swepub:umu)frre0001 (author)
  • Ye, WeiminKarolinska Institutet,Umeå universitet,Enheten för biobanksforskning,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Swede (author)
  • Wareham, Nick (author)
  • Khaw, Kay-Tee (author)
  • Bradbury, Kathryn E. (author)
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  • Aune, Dagfinn (author)
  • Norat, Teresa (author)
  • Riboli, Elio (author)
  • Bueno-de-Mesquita, H. B(as) (author)
  • Karolinska InstitutetGenetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden (creator_code:org_t)

Related titles

  • In:International Journal of Cancer: WILEY142:6, s. 1189-12010020-71361097-0215

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