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Circulating concent...
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van Duijnhoven, Fraenzel J. B.
(author)
Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2017-11-22
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WILEY,2018
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-144331
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-144331URI
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https://doi.org/10.1002/ijc.31146DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:137431930URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-TrOndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n=626; HUNT2 n=112; median follow-up=6.9 years) were matched to 738 controls. Vitamin D [25(OH)D-2 and 25(OH)D-3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of 25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend=0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend=0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.
Subject headings and genre
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Jenab, Mazda
(author)
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Hveem, Kristian
(author)
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Siersema, Peter D.
(author)
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Fedirko, Veronika
(author)
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Duell, Eric J.
(author)
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Kampman, Ellen
(author)
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Halfweeg, Anouk
(author)
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van Kranen, Henk J.
(author)
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van den Ouweland, Jody M. W.
(author)
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Weiderpass, ElisabeteKarolinska Institutet
(author)
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Murphy, Neil
(author)
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Langhammer, Arnulf
(author)
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Ness-Jensen, EivindKarolinska Institutet
(author)
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Olsen, Anja
(author)
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Tjonneland, Anne
(author)
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Overvad, Kim
(author)
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Cadeau, Claire
(author)
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Kvaskoff, Marina
(author)
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Boutron-Ruault, Marie-Christine
(author)
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Katzke, Verena A.
(author)
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Kuehn, Tilman
(author)
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Boeing, Heiner
(author)
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Trichopoulou, Antonia
(author)
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Kotanidou, Anastasia
(author)
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Kritikou, Maria
(author)
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Palli, Domenico
(author)
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Agnoli, Claudia
(author)
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Tumino, Rosario
(author)
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Panico, Salvatore
(author)
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Matullo, Giuseppe
(author)
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Peeters, Petra
(author)
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Brustad, Magritt
(author)
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Olsen, Karina Standahl
(author)
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Lasheras, Cristina
(author)
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Obon-Santacana, Mireia
(author)
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Sanchez, Maria-Jose
(author)
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Dorronsoro, Miren
(author)
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Chirlaque, Maria-Dolores
(author)
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Barricarte, Aurelio
(author)
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Manjer, Jonas
(author)
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Almquist, Martin
(author)
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Renström, FridaGenetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden(Swepub:umu)frre0001
(author)
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Ye, WeiminKarolinska Institutet,Umeå universitet,Enheten för biobanksforskning,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Swede
(author)
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Wareham, Nick
(author)
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Khaw, Kay-Tee
(author)
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Bradbury, Kathryn E.
(author)
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Freisling, Heinz
(author)
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Aune, Dagfinn
(author)
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Norat, Teresa
(author)
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Riboli, Elio
(author)
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Bueno-de-Mesquita, H. B(as)
(author)
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Karolinska InstitutetGenetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden
(creator_code:org_t)
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In:International Journal of Cancer: WILEY142:6, s. 1189-12010020-71361097-0215
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van Duijnhoven, ...
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Jenab, Mazda
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Hveem, Kristian
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Siersema, Peter ...
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Fedirko, Veronik ...
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Duell, Eric J.
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van Kranen, Henk ...
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Ness-Jensen, Eiv ...
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Katzke, Verena A ...
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Kritikou, Maria
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