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Vitamin D status and dental caries in healthy Swedish children
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- Gyll, Johanna (author)
- Umeå University,Umeå universitet,Institutionen för odontologi,Department of Odontology, Section of Paediatric Dentistry, Faculty of Medicine, Umeå University, 90185, Umeå, Sweden
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- Ridell, Karin (author)
- Malmö University,Malmö universitet,Odontologiska fakulteten (OD)
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- Öhlund, Inger (author)
- Umeå University,Umeå universitet,Pediatrik,Department of Clinical Sciences/Section of Paediatric Medicine, Faculty of Medicine, Umeå University, Umeå, Sweden
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- 2018-01-16
- 2018
- English.
- In: Nutrition Journal. - London : BioMed Central. - 1475-2891. ; 17
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Background: Vitamin D is crucial for mineralized tissue formation and immunological functions. The purpose of this study was to evaluate the association between vitamin D status and dental status in healthy children with vitamin D supplementation in infancy and at 6 years of age.Method: Eight-year-old children who had participated, in a vitamin D intervention project when they were 6 years old were invited to participate in a dental follow-up study. They had fair or darker skin complexion and represented two geographically distant parts of Sweden. 25-hydroxy vitamin D in serum had been measured at 6 years of age and after a 3-month intervention with 25, 10 or 2 (placebo) mu g of vitamin D-3 per day. Two years later, caries and enamel defects were scored, self-reported information on e.g., oral behavior, dietary habits and intake of vitamin D supplements was collected, and innate immunity peptide LL37 levels in saliva and cariogenic mutant streptococci in tooth biofilm were analyzed. The outcome variables were caries and tooth enamel defects.Results: Dental status was evaluated in 85 of the 206 children in the basic intervention study. Low vitamin D levels were found in 28% at baseline compared to 11% after the intervention, and 34% reported continued intake of vitamin D supplements. Logistic regression supported a weak inverse association between vitamin D status at 6 years of age and caries 2 years later (odds ratio 0.96; p = 0.024) with minor attenuation after an adjustment for potential confounders. Multivariate projection regression confirmed that insufficient vitamin D levels correlated with caries and higher vitamin D levels correlated with being caries-free. Vitamin D status at 6 years of age was unrelated to enamel defects but was positively associated with saliva LL37 levels.Conclusion: An association between vitamin D status and caries was supported, but it was not completely consistent. Vitamin D status at 6 years of age was unrelated to enamel defects but was positively associated with LL37 expression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Keyword
- Vitamin D
- Children
- caries
- enamel defects
- LL37
- caries
- Children
- enamel defects
- LL37
- Vitamin D
Publication and Content Type
- ref (subject category)
- art (subject category)
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