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The HRD-Algorithm :
The HRD-Algorithm : a general method for parametric estimation of two-component mixture models
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- Rydén, Patrik (author)
- Umeå universitet,Institutionen för matematik och matematisk statistik,Patrik Rydén
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- Källberg, David, 1982- (author)
- Umeå universitet,Institutionen för matematik och matematisk statistik
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- Belyaev, Yu. K. (author)
- Umeå universitet,Institutionen för matematik och matematisk statistik
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(creator_code:org_t)
- 2017-12-21
- 2017
- English.
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In: Lecture Notes in Computer Science. - Cham : Springer. - 0302-9743 .- 1611-3349. ; 10684, s. 497-508
- Related links:
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https://urn.kb.se/re...
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Abstract
Subject headings
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- We introduce a novel approach to estimate the parameters of a mixture of two distributions. The method combines a grid approach with the method of moments and can be applied to a wide range of two-component mixture models. The grid approach enables the use of parallel computing and the method can easily be combined with resampling techniques. We derive the method for the special cases when the data are described by the mixture of two Weibull distributions or the mixture of two normal distributions, and apply the method on gene expression data from 409 ER+" role="presentation" style="box-sizing: border-box; display: inline-table; line-height: normal; letter-spacing: normal; word-spacing: normal; word-wrap: normal; white-space: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: 0px; min-height: 0px; border: 0px; padding: 0px; margin: 0px; position: relative;">ER+ER+ breast cancer patients.
Subject headings
- NATURVETENSKAP -- Matematik -- Sannolikhetsteori och statistik (hsv//swe)
- NATURAL SCIENCES -- Mathematics -- Probability Theory and Statistics (hsv//eng)
Keyword
- Mixture models
- Parameter estimation
- Method of moments Grid-approach
- Resampling
- Cluster analysis Variable selection
- High-dimensional data
- matematisk statistik
- Mathematical Statistics
Publication and Content Type
- ref (subject category)
- art (subject category)
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