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Indoor bacteria and...
Indoor bacteria and asthma in adults : a multicentre case-control study within ECRHS II
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- Pekkanen, Juha (author)
- Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.;Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland.
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- Valkonen, Maria (author)
- Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland.;Univ Eastern Finland, Dept Environm & Biol Sci, Kuopio, Finland.
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- Täubel, Martin (author)
- Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland.
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- Tischer, Christina (author)
- ISGlobal, Barcelona Inst Global Hlth, Barcelona, Spain.;Univ Pompeu Fabra, Barcelona, Spain.;CIBER Epidemiol Salud Publ, CIBERESP, Madrid, Spain.
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- Leppänen, Hanna (author)
- Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland.
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- Kärkkäinen, Päivi M (author)
- Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland.
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- Rintala, Helena (author)
- Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland.
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- Zock, Jan-Paul (author)
- ISGlobal, Barcelona Inst Global Hlth, Barcelona, Spain.;Univ Pompeu Fabra, Barcelona, Spain.;CIBER Epidemiol Salud Publ, CIBERESP, Madrid, Spain.
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- Casas, Lidia (author)
- Katholieke Univ Leuven, Ctr Environm & Hlth, Dept Publ Hlth & Primary Care, Leuven, Belgium.
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- Probst-Hensch, Nicole (author)
- Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.;Univ Basel, Dept Publ Hlth, Basel, Switzerland.
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- Forsberg, Bertil (author)
- Umeå universitet,Yrkes- och miljömedicin,Umea Univ, Dept Publ Hlth & Clin Med Occupat & Environm Me, Umea, Sweden.
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- Holm, Mathias (author)
- Sahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden.
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- Janson, Christer (author)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Pin, Isabelle (author)
- Univ Grenoble Alpes, CHU Grenoble Alpes, Grenoble, France.
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- Gislason, Thorarinn (author)
- Landspitali Univ Hosp, Dept Resp Med & Sleep, E7, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.
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- Jarvis, Debbie (author)
- Natl Heart & Lung Inst, Imperial Coll, Populat Hlth & Occupat Dis, London, England.;Imperial Coll, MRC PHE Ctr Environm & Hlth, London, England.
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- Heinrich, Joachim (author)
- Ludwig Maximillians Univ Munich, Univ Hosp Munich, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol 1, Helmholtz Zentrum Munchen, Neuherberg, Germany.
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- Hyvärinen, Anne (author)
- Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.
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Univ Helsinki, Dept Publ Hlth, Helsinki, Finland;Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland. Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland.;Univ Eastern Finland, Dept Environm & Biol Sci, Kuopio, Finland. (creator_code:org_t)
- 2018-02-07
- 2018
- English.
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In: European Respiratory Journal. - : European Respiratory Society (ERS). - 0903-1936 .- 1399-3003. ; 51:2
- Related links:
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https://erj.ersjourn...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- Both protective and adverse effects of indoor microbial exposure on asthma have been reported, but mostly in children. To date, no study in adults has used non-targeted methods for detection of indoor bacteria followed by quantitative confirmation. A cross-sectional study of 198 asthmatic and 199 controls was conducted within the European Community Respiratory Health Survey (ECRHS) II. DNA was extracted from mattress dust for bacterial analysis using denaturing gradient gel electrophoresis (DGGE). Selected bands were sequenced and associations with asthma confirmed with four quantitative PCR (qPCR) assays. 15 out of 37 bands detected with DGGE, which had at least a suggestive association (p<0.25) with asthma, were sequenced. Of the four targeted qPCRs, Clostridium cluster XI confirmed the protective association with asthma. The association was dose dependent (aOR 0.43 (95% CI 0.22-0.84) for the fourth versus first quartile, p for trend 0.009) and independent of other microbial markers. Few significant associations were observed for the three other qPCRs used. In this large international study, the level of Clostridium cluster XI was independently associated with a lower risk of prevalent asthma. Results suggest the importance of environmental bacteria also in adult asthma, but need to be confirmed in future studies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Pekkanen, Juha
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Valkonen, Maria
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Täubel, Martin
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Tischer, Christi ...
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Leppänen, Hanna
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Kärkkäinen, Päiv ...
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show more...
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Rintala, Helena
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Zock, Jan-Paul
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Casas, Lidia
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Probst-Hensch, N ...
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Forsberg, Bertil
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Holm, Mathias
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Janson, Christer
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Pin, Isabelle
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Gislason, Thorar ...
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Jarvis, Debbie
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Heinrich, Joachi ...
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Hyvärinen, Anne
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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European Respira ...
- By the university
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Umeå University
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Uppsala University