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  • Pekkanen, JuhaUniv Helsinki, Dept Publ Hlth, Helsinki, Finland.;Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland. (author)

Indoor bacteria and asthma in adults : a multicentre case-control study within ECRHS II

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-02-07
  • European Respiratory Society (ERS),2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-144812
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-144812URI
  • https://doi.org/10.1183/13993003.01241-2017DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-346883URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Both protective and adverse effects of indoor microbial exposure on asthma have been reported, but mostly in children. To date, no study in adults has used non-targeted methods for detection of indoor bacteria followed by quantitative confirmation. A cross-sectional study of 198 asthmatic and 199 controls was conducted within the European Community Respiratory Health Survey (ECRHS) II. DNA was extracted from mattress dust for bacterial analysis using denaturing gradient gel electrophoresis (DGGE). Selected bands were sequenced and associations with asthma confirmed with four quantitative PCR (qPCR) assays. 15 out of 37 bands detected with DGGE, which had at least a suggestive association (p<0.25) with asthma, were sequenced. Of the four targeted qPCRs, Clostridium cluster XI confirmed the protective association with asthma. The association was dose dependent (aOR 0.43 (95% CI 0.22-0.84) for the fourth versus first quartile, p for trend 0.009) and independent of other microbial markers. Few significant associations were observed for the three other qPCRs used. In this large international study, the level of Clostridium cluster XI was independently associated with a lower risk of prevalent asthma. Results suggest the importance of environmental bacteria also in adult asthma, but need to be confirmed in future studies.

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  • Valkonen, MariaNatl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland.;Univ Eastern Finland, Dept Environm & Biol Sci, Kuopio, Finland. (author)
  • Täubel, MartinNatl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland. (author)
  • Tischer, ChristinaISGlobal, Barcelona Inst Global Hlth, Barcelona, Spain.;Univ Pompeu Fabra, Barcelona, Spain.;CIBER Epidemiol Salud Publ, CIBERESP, Madrid, Spain. (author)
  • Leppänen, HannaNatl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland. (author)
  • Kärkkäinen, Päivi MNatl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland. (author)
  • Rintala, HelenaNatl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland. (author)
  • Zock, Jan-PaulISGlobal, Barcelona Inst Global Hlth, Barcelona, Spain.;Univ Pompeu Fabra, Barcelona, Spain.;CIBER Epidemiol Salud Publ, CIBERESP, Madrid, Spain. (author)
  • Casas, LidiaKatholieke Univ Leuven, Ctr Environm & Hlth, Dept Publ Hlth & Primary Care, Leuven, Belgium. (author)
  • Probst-Hensch, NicoleSwiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.;Univ Basel, Dept Publ Hlth, Basel, Switzerland. (author)
  • Forsberg, BertilUmeå universitet,Yrkes- och miljömedicin,Umea Univ, Dept Publ Hlth & Clin Med Occupat & Environm Me, Umea, Sweden.(Swepub:umu)befo0001 (author)
  • Holm, MathiasSahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden. (author)
  • Janson, ChristerUppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)chrisjn (author)
  • Pin, IsabelleUniv Grenoble Alpes, CHU Grenoble Alpes, Grenoble, France. (author)
  • Gislason, ThorarinnLandspitali Univ Hosp, Dept Resp Med & Sleep, E7, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland. (author)
  • Jarvis, DebbieNatl Heart & Lung Inst, Imperial Coll, Populat Hlth & Occupat Dis, London, England.;Imperial Coll, MRC PHE Ctr Environm & Hlth, London, England. (author)
  • Heinrich, JoachimLudwig Maximillians Univ Munich, Univ Hosp Munich, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol 1, Helmholtz Zentrum Munchen, Neuherberg, Germany. (author)
  • Hyvärinen, AnneUniv Helsinki, Dept Publ Hlth, Helsinki, Finland. (author)
  • Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.;Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland.Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland.;Univ Eastern Finland, Dept Environm & Biol Sci, Kuopio, Finland. (creator_code:org_t)

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  • In:European Respiratory Journal: European Respiratory Society (ERS)51:20903-19361399-3003

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