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Comparative genomic...
Comparative genomic analysis of Lactobacillus mucosae LM1 identifies potential niche-specific genes and pathways for gastrointestinal adaptation
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- Valeriano, Valerie Diane (author)
- Department of Animal Resources Science, Dankook University, Cheonan 31116, Republic of Korea
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- Oh, Ju Kyoung (author)
- Dankook University
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- Bagon, Bernadette (author)
- Dankook University
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- Kim, Heebal (author)
- Seoul National University
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- Kang, Dae-Kyung (author)
- Dankook University
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(creator_code:org_t)
- Elsevier, 2019
- 2019
- English.
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In: Genomics. - : Elsevier. - 0888-7543 .- 1089-8646. ; 111:1, s. 24-33
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https://doi.org/10.1...
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Abstract
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- Lactobacillus mucosae is currently of interest as putative probiotics due to their metabolic capabilities and ability to colonize host mucosal niches. L. mucosae LM1 has been studied in its functions in cell adhesion and pathogen inhibition, etc. It demonstrated unique abilities to use energy from carbohydrate and non-carbohydrate sources. Due to these functions, we report the first complete genome sequence of an L. mucosae strain, L. mucosae LM1. Analysis of the pan-genome in comparison with closely-related Lactobacillus species identified a complete glycogen metabolism pathway, as well as folate biosynthesis, complementing previous proteomic data on the LM1 strain. It also revealed common and unique niche-adaptation genes among the various L. mucosae strains. The aim of this study was to derive genomic information that would reveal the probable mechanisms underlying the probiotic effect of L. mucosae LM1, and provide a better understanding of the nature of L. mucosae sp.
Subject headings
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Keyword
- Lactobacillus mucosae
- Comparative genomics
- Probiotics
Publication and Content Type
- ref (subject category)
- art (subject category)
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