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Longitudinal relati...
Longitudinal relationships among depressive symptoms, cortisol, and brain atrophy in the neocortex and the hippocampus
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Lebedeva, A (author)
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- Sundström, Anna (author)
- Umeå universitet,Enheten för demografi och åldrandeforskning (CEDAR),Institutionen för psykologi
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- Lindgren, Lenita (author)
- Umeå universitet,Institutionen för omvårdnad,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Stomby, Andreas (author)
- Umeå universitet,Avdelningen för medicin,Jönköping County Hospital, Region Jönköping County, Jönköping, Sweden
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- Aarsland, D (author)
- Karolinska Institutet
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- Westman, E (author)
- Karolinska Institutet
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- Winblad, B (author)
- Karolinska Institutet
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- Olsson, Tommy (author)
- Umeå universitet,Avdelningen för medicin
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- Nyberg, Lars, 1966- (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi,Fysiologi
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(creator_code:org_t)
- 2018-02-18
- 2018
- English.
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In: Acta Psychiatrica Scandinavica. - : John Wiley & Sons. - 0001-690X .- 1600-0447. ; 167:6, s. 491-502
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- OBJECTIVE: Depression is associated with accelerated aging and age-related diseases. However, mechanisms underlying this relationship remain unclear. The aim of this study was to longitudinally assess the link between depressive symptoms, brain atrophy, and cortisol levels.METHOD: Participants from the Betula prospective cohort study (mean age = 59 years, SD = 13.4 years) underwent clinical, neuropsychological and brain 3T MRI assessments at baseline and a 4-year follow-up. Cortisol levels were measured at baseline in four saliva samples. Cortical and hippocampal atrophy rates were estimated and compared between participants with and without depressive symptoms (n = 81) and correlated with cortisol levels (n = 49).RESULTS: Atrophy in the left superior frontal gyrus and right lingual gyrus developed in parallel with depressive symptoms, and in the left temporal pole, superior temporal cortex, and supramarginal cortex after the onset of depressive symptom. Depression-related atrophy was significantly associated with elevated cortisol levels. Elevated cortisol levels were also associated with widespread prefrontal, parietal, lateral, and medial temporal atrophy.CONCLUSION: Depressive symptoms and elevated cortisol levels are associated with atrophy of the prefrontal and limbic areas of the brain.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- depressive symptomatology
- neuroimaging
- superior temporal gyrus
- superior frontal gyrus
- MRI
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Lebedeva, A
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Sundström, Anna
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Lindgren, Lenita
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Stomby, Andreas
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Aarsland, D
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Westman, E
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show more...
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Winblad, B
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Olsson, Tommy
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Nyberg, Lars, 19 ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nursing
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Acta Psychiatric ...
- By the university
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Umeå University
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Karolinska Institutet