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A Genome-wide Droso...
A Genome-wide Drosophila Screen for Heat Nociception Identifies alpha 2 delta 3 as an Evolutionarily Conserved Pain Gene
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- Neely, G Gregory (author)
- Austrian Academy of Science
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- Hess, Andreas (author)
- University of Erlangen Nurnberg
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- Costigan, Michael (author)
- Harvard University
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- Keene, Alex C (author)
- NYU
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- Goulas, Spyros (author)
- Austrian Academy of Science
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- Langeslag, Michiel (author)
- Innsbruck Medical University
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- Griffin, Robert S (author)
- Massachusetts General Hospital,Strand Life Science Pvt Ltd
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- Belfer, Inna (author)
- University of Pittsburgh
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- Dai, Feng (author)
- University of Pittsburgh
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- Smith, Shad B (author)
- University N Carolina
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- Diatchenko, Luda (author)
- University N Carolina
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- Gupta, Vaijayanti (author)
- Strand Life Science Pvt Ltd
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- Xia, Cui-Ping (author)
- Austrian Academy Science
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- Amann, Sabina (author)
- Austrian Academy of Science
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- Kreitz, Silke (author)
- University of Erlangen Nurnberg
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- Heindl-Erdmann, Cornelia (author)
- University of Erlangen Nurnberg
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- Wolz, Susanne (author)
- University of Erlangen Nurnberg
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- Ly, Cindy V (author)
- Strand Life Science Pvt Ltd
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- Sarangi, Rinku (author)
- Strand Life Science Pvt Ltd
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- Dan, Debasis (author)
- Strand Life Science Pvt Ltd
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- Novatchkova, Maria (author)
- Austrian Academy of Science
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- Rosenzweig, Mark (author)
- Brandeis University
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- Gibson, Dustin G (author)
- University N Carolina
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- Truong, Darwin (author)
- Austrian Academy of Science
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- Schramek, Daniel (author)
- Austrian Academy of Science
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- Zoranovic, Tamara (author)
- Austrian Academy of Science
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- Cronin, Shane J F (author)
- Austrian Academy of Science
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- Angjeli, Belinda (author)
- Austrian Academy of Science
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- Brune, Kay (author)
- University of Erlangen Nurnberg
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- Dietzl, Georg (author)
- Stanford University
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- Maixner, William (author)
- University N Carolina
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- Meixner, Arabella (author)
- Austrian Academy of Science
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- Thomas, Winston (author)
- Deltagen Inc
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- Pospisilik, J Andrew (author)
- Max Planck Institute
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- Alenius, Mattias (author)
- Linköpings universitet,Hälsouniversitetet,Utvecklingsbiologi
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- Kress, Michaela (author)
- Innsbruck Medical University
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- Subramaniam, Sai (author)
- Strand Life Science Pvt Ltd
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- Garrity, Paul A (author)
- Brandeis University
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- Bellen, Hugo J (author)
- Baylor College of Medicine
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- Woolf, Clifford J (author)
- Harvard University
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- Penninger, Josef M (author)
- Austrian Academy of Science
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(creator_code:org_t)
- Elsevier Science B.V., Amsterdam. 2010
- 2010
- English.
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In: Cell. - : Elsevier Science B.V., Amsterdam.. - 0092-8674 .- 1097-4172. ; 143:4, s. 628-638
- Related links:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Worldwide, acute, and chronic pain affects 20% of the adult population and represents an enormous financial and emotional burden. Using genome-wide neuronal-specific RNAi knockdown in Drosophila, we report a global screen for an innate behavior and identify hundreds of genes implicated in heat nociception, including the alpha 2 delta family calcium channel subunit straightjacket (stj). Mice mutant for the stj ortholog CACNA2D3 (alpha 2 delta 3) also exhibit impaired behavioral heat pain sensitivity. In addition, in humans, alpha 2 delta 3 SNP variants associate with reduced sensitivity to acute noxious heat and chronic back pain. Functional imaging in alpha 2 delta 3 mutant mice revealed impaired transmission of thermal pain-evoked signals from the thalamus to higher-order pain centers. Intriguingly, in alpha 2 delta 3 mutant mice, thermal pain and tactile stimulation triggered strong cross-activation, or synesthesia, of brain regions involved in vision, olfaction, and hearing.
Keyword
- MEDICINE
- MEDICIN
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- ref (subject category)
- art (subject category)
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Cell
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- By the author/editor
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Neely, G Gregory
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Hess, Andreas
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Costigan, Michae ...
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Keene, Alex C
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Goulas, Spyros
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Langeslag, Michi ...
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show more...
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Griffin, Robert ...
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Belfer, Inna
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Dai, Feng
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Smith, Shad B
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Diatchenko, Luda
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Gupta, Vaijayant ...
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Xia, Cui-Ping
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Amann, Sabina
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Kreitz, Silke
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Heindl-Erdmann, ...
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Wolz, Susanne
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Ly, Cindy V
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Sarangi, Rinku
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Dan, Debasis
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Novatchkova, Mar ...
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Rosenzweig, Mark
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Gibson, Dustin G
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Truong, Darwin
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Schramek, Daniel
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Zoranovic, Tamar ...
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Cronin, Shane J ...
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Angjeli, Belinda
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Brune, Kay
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Dietzl, Georg
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Maixner, William
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Meixner, Arabell ...
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Thomas, Winston
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Pospisilik, J An ...
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Alenius, Mattias
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Kress, Michaela
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Subramaniam, Sai
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Garrity, Paul A
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Bellen, Hugo J
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Woolf, Clifford ...
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Penninger, Josef ...
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show less...
- Articles in the publication
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Cell
- By the university
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Umeå University
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Linköping University