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A synbiotic-contain...
A synbiotic-containing amino-acid-based formula improves gut microbiota in non-IgE-mediated allergic infants
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Candy, David C. A. (author)
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Van Ampting, Marleen T. J. (author)
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Nijhuis, Manon M. Oude (author)
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Wopereis, Harm (author)
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Butt, Assad M. (author)
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Peroni, Diego G. (author)
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Vandenplas, Yvan (author)
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Fox, Adam T. (author)
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Shah, Neil (author)
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- West, Christina E. (author)
- Umeå universitet,Pediatrik
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Garssen, Johan (author)
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Harthoorn, Lucien F. (author)
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Knol, Jan (author)
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Michaelis, Louise J. (author)
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(creator_code:org_t)
- 2017-12-06
- 2018
- English.
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In: Pediatric Research. - : Springer Science and Business Media LLC. - 0031-3998 .- 1530-0447. ; 83:3, s. 677-686
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Prebiotics and probiotics (synbiotics) can modify gut microbiota and have potential in allergy management when combined with amino-acid-based formula (AAF) for infants with cow’s milk allergy (CMA).Methods: This multicenter, double-blind, randomized controlled trial investigated the effects of an AAF-including synbiotic blend on percentages of bifidobacteria and Eubacterium rectale/Clostridium coccoides group (ER/CC) in feces from infants with suspected non-IgE-mediated CMA. Feces from age-matched healthy breastfed infants were used as reference (healthy breastfed reference (HBR)) for primary outcomes. The CMA subjects were randomized and received test or control formula for 8 weeks. Test formula was a hypoallergenic, nutritionally complete AAF including a prebiotic blend of fructo-oligosaccharides and the probiotic strain Bifidobacterium breve M-16V. Control formula was AAF without synbiotics.Results: A total of 35 (test) and 36 (control) subjects were randomized; HBR included 51 infants. At week 8, the median percentage of bifidobacteria was higher in the test group than in the control group (35.4% vs. 9.7%, respectively; P<0.001), whereas ER/CC was lower (9.5% vs. 24.2%, respectively; P<0.001). HBR levels of bifidobacteria and ER/CC were 55% and 6.5%, respectively.Conclusion: AAF including specific synbiotics, which results in levels of bifidobacteria and ER/CC approximating levels in the HBR group, improves the fecal microbiota of infants with suspected non-IgE-mediated CMA.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Candy, David C. ...
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Van Ampting, Mar ...
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Nijhuis, Manon M ...
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Wopereis, Harm
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Butt, Assad M.
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Peroni, Diego G.
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show more...
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Vandenplas, Yvan
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Fox, Adam T.
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Shah, Neil
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West, Christina ...
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Garssen, Johan
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Harthoorn, Lucie ...
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Knol, Jan
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Michaelis, Louis ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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Pediatric Resear ...
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Umeå University