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Left Ventricular Isovolumetric Relaxation Time Is Prolonged in Fetal Long-QT Syndrome
- Clur, Sally-Ann B (author)
- Vink, Arja S (author)
- Etheridge, Susan P (author)
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- Robles de Medina, Pascale G (author)
- Ackerman, Michael J (author)
- Wilde, Arthur A (author)
- Blom, Nico A (author)
- Benson, D Woodrow (author)
- Herberg, Ulrike (author)
- Donofrio, Mary T (author)
- Cuneo, Bettina F (author)
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- (creator_code:org_t)
- Lippincott Williams & Wilkins, 2018
- 2018
- English.
- In: Circulation. - : Lippincott Williams & Wilkins. - 1941-3149 .- 1941-3084. ; 11:4
- Journal article (peer-reviewed)
Abstract
Subject headings
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- BACKGROUND: Long-QT syndrome (LQTS), an inherited cardiac repolarization disorder, is an important cause of fetal and neonatal mortality. Detecting LQTS prenatally is challenging. A fetal heart rate (FHR) less than third percentile for gestational age is specific for LQTS, but the sensitivity is only ≈50%. Left ventricular isovolumetric relaxation time (LVIRT) was evaluated as a potential diagnostic marker for fetal LQTS.METHODS AND RESULTS: <0.001), as was the N-LVIRT. The best cutoff to diagnose LQTS was N-LVIRT ≥11.3 at ≤20 weeks (92% sensitivity, 70% specificity). Simultaneous analysis of N-LVIRT and FHR improved the sensitivity and specificity for LQTS (area under the curve=0.96; 95% confidence interval, 0.82-1.00 at 21-30 weeks). N-LVIRT, LV myocardial performance index, and FHR trends differed significantly between LQTS fetuses and controls through gestation.CONCLUSIONS: The LVIRT is prolonged in LQTS fetuses. Findings of a prolonged N-LVIRT and sinus bradycardia can improve the prenatal detection of fetal LQTS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- Doppler
- fetus
- gestational age
- heart rate
- isovolumetric relaxation time
- long QT syndrome
- prenatal diagnosis
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- ref (subject category)
- art (subject category)
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- Wilde, Arthur A
- Blom, Nico A
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- Herberg, Ulrike
- Donofrio, Mary T
- Cuneo, Bettina F
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- MEDICAL AND HEALTH SCIENCES
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- Circulation
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- Umeå University
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