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Influence of obesit...
Influence of obesity-related risk factors in the aetiology of glioma
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Disney-Hogg, Linden (author)
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Sud, Amit (author)
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Law, Philip J. (author)
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Cornish, Alex J. (author)
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Kinnersley, Ben (author)
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Ostrom, Quinn T. (author)
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Labreche, Karim (author)
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Eckel-Passow, Jeanette E. (author)
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Armstrong, Georgina N. (author)
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Claus, Elizabeth B. (author)
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Il'yasova, Dora (author)
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Schildkraut, Joellen (author)
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Barnholtz-Sloan, Jill S. (author)
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Olson, Sara H. (author)
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Bernstein, Jonine L. (author)
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Lai, Rose K. (author)
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Swerdlow, Anthony J. (author)
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Simon, Matthias (author)
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Hoffmann, Per (author)
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Nöthen, Markus M. (author)
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Jöckel, Karl-Heinz (author)
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Chanock, Stephen (author)
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Rajaraman, Preetha (author)
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Johansen, Christoffer (author)
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Jenkins, Robert B. (author)
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- Melin, Beatrice S. (author)
- Umeå universitet,Onkologi
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Wrensch, Margaret R. (author)
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Sanson, Marc (author)
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Bondy, Melissa L. (author)
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Houlston, Richard S. (author)
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(creator_code:org_t)
- 2018-03-13
- 2018
- English.
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In: British Journal of Cancer. - : Nature Publishing Group. - 0007-0920 .- 1532-1827. ; 118:7, s. 1020-1027
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation framework to examine whether obesity-related traits influence glioma risk. This methodology reduces bias from confounding and is not affected by reverse causation. METHODS: Genetic instruments were identified for 10 key obesity-related risk factors, and their association with glioma risk was evaluated using data from a genome-wide association study of 12,488 glioma patients and 18,169 controls. The estimated odds ratio of glioma associated with each of the genetically defined obesity-related traits was used to infer evidence for a causal relationship. RESULTS: No convincing association with glioma risk was seen for genetic instruments for body mass index, waist-to-hip ratio, lipids, type-2 diabetes, hyperglycaemia or insulin resistance. Similarly, we found no evidence to support a relationship between obesity-related traits with subtypes of glioma-glioblastoma (GBM) or non-GBM tumours. CONCLUSIONS: This study provides no evidence to implicate obesity-related factors as causes of glioma.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Disney-Hogg, Lin ...
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Sud, Amit
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Law, Philip J.
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Cornish, Alex J.
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Kinnersley, Ben
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Ostrom, Quinn T.
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show more...
-
Labreche, Karim
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Eckel-Passow, Je ...
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Armstrong, Georg ...
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Claus, Elizabeth ...
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Il'yasova, Dora
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Schildkraut, Joe ...
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Barnholtz-Sloan, ...
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Olson, Sara H.
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Bernstein, Jonin ...
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Lai, Rose K.
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Swerdlow, Anthon ...
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Simon, Matthias
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Hoffmann, Per
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Nöthen, Markus M ...
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Jöckel, Karl-Hei ...
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Chanock, Stephen
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Rajaraman, Preet ...
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Johansen, Christ ...
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Jenkins, Robert ...
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Melin, Beatrice ...
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Wrensch, Margare ...
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Sanson, Marc
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Bondy, Melissa L ...
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Houlston, Richar ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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British Journal ...
- By the university
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Umeå University