Search: onr:"swepub:oai:DiVA.org:umu-148648" >
Influence of obesit...
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Disney-Hogg, Linden
(author)
Influence of obesity-related risk factors in the aetiology of glioma
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-03-13
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Nature Publishing Group,2018
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-148648
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-148648URI
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https://doi.org/10.1038/s41416-018-0009-xDOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation framework to examine whether obesity-related traits influence glioma risk. This methodology reduces bias from confounding and is not affected by reverse causation. METHODS: Genetic instruments were identified for 10 key obesity-related risk factors, and their association with glioma risk was evaluated using data from a genome-wide association study of 12,488 glioma patients and 18,169 controls. The estimated odds ratio of glioma associated with each of the genetically defined obesity-related traits was used to infer evidence for a causal relationship. RESULTS: No convincing association with glioma risk was seen for genetic instruments for body mass index, waist-to-hip ratio, lipids, type-2 diabetes, hyperglycaemia or insulin resistance. Similarly, we found no evidence to support a relationship between obesity-related traits with subtypes of glioma-glioblastoma (GBM) or non-GBM tumours. CONCLUSIONS: This study provides no evidence to implicate obesity-related factors as causes of glioma.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Sud, Amit
(author)
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Law, Philip J.
(author)
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Cornish, Alex J.
(author)
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Kinnersley, Ben
(author)
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Ostrom, Quinn T.
(author)
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Labreche, Karim
(author)
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Eckel-Passow, Jeanette E.
(author)
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Armstrong, Georgina N.
(author)
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Claus, Elizabeth B.
(author)
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Il'yasova, Dora
(author)
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Schildkraut, Joellen
(author)
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Barnholtz-Sloan, Jill S.
(author)
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Olson, Sara H.
(author)
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Bernstein, Jonine L.
(author)
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Lai, Rose K.
(author)
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Swerdlow, Anthony J.
(author)
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Simon, Matthias
(author)
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Hoffmann, Per
(author)
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Nöthen, Markus M.
(author)
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Jöckel, Karl-Heinz
(author)
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Chanock, Stephen
(author)
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Rajaraman, Preetha
(author)
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Johansen, Christoffer
(author)
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Jenkins, Robert B.
(author)
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Melin, Beatrice S.Umeå universitet,Onkologi(Swepub:umu)bema0010
(author)
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Wrensch, Margaret R.
(author)
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Sanson, Marc
(author)
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Bondy, Melissa L.
(author)
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Houlston, Richard S.
(author)
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Umeå universitetOnkologi
(creator_code:org_t)
Related titles
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In:British Journal of Cancer: Nature Publishing Group118:7, s. 1020-10270007-09201532-1827
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Disney-Hogg, Lin ...
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Sud, Amit
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Law, Philip J.
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Cornish, Alex J.
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Kinnersley, Ben
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Ostrom, Quinn T.
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Labreche, Karim
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Eckel-Passow, Je ...
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Armstrong, Georg ...
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Claus, Elizabeth ...
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Il'yasova, Dora
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Schildkraut, Joe ...
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Barnholtz-Sloan, ...
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Olson, Sara H.
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Bernstein, Jonin ...
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Lai, Rose K.
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Swerdlow, Anthon ...
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Simon, Matthias
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Hoffmann, Per
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Nöthen, Markus M ...
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Jöckel, Karl-Hei ...
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Chanock, Stephen
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Rajaraman, Preet ...
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Johansen, Christ ...
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Jenkins, Robert ...
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Melin, Beatrice ...
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Wrensch, Margare ...
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Sanson, Marc
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Bondy, Melissa L ...
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Houlston, Richar ...
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