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Association of gluc...
Association of glucocerebrosidase polymorphisms and mutations with dementia in incident Parkinson's disease
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- Lunde, Kristin Aaser (author)
- Umeå universitet,Klinisk neurovetenskap
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Chung, Janete (author)
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Dalen, Ingvild (author)
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Pedersen, Kenn Freddy (author)
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- Linder, Jan (author)
- Umeå universitet,Klinisk neurovetenskap
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- Domellöf, Magdalena E. (author)
- Umeå universitet,Institutionen för psykologi,Klinisk neurovetenskap
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- Elgh, Eva (author)
- Umeå universitet,Institutionen för psykologi
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Macleod, Agnus D (author)
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Tzoulis, Charalampos (author)
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Larsen, Jan-Petter (author)
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Tysnen, Ole-Bjørn (author)
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- Forsgren, Lars (author)
- Umeå universitet,Klinisk neurovetenskap
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Counsell, Carl E. (author)
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Alves, Guido (author)
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Maple-Grødem, Jodi (author)
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(creator_code:org_t)
- 2018-05-21
- 2018
- English.
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In: Alzheimer's & Dementia. - : Elsevier. - 1552-5260 .- 1552-5279. ; 14:10, s. 1293-1301
- Related links:
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https://aura.abdn.ac...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- IntroductionBoth polymorphisms and mutations in glucocerebrosidase (GBA) may influence the development of dementia in patients with Parkinson's disease.MethodsFour hundred forty-two patients and 419 controls were followed for 7 years. Dementia was diagnosed using established criteria. Participants were analyzed for GBA genetic variants, including E326K, T369M, and L444P. Associations between GBA carrier status and dementia were assessed with Cox survival analysis.ResultsA total of 12.0% of patients with Parkinson's disease carried a GBA variant, and nearly half (22/53) of them progressed to dementia during follow-up. Carriers of deleterious GBA mutations (adjusted hazard ratio 3.81, 95% confidence interval 1.35 to 10.72; P = .011) or polymorphisms (adjusted hazard ratio 1.79; 95% confidence interval 1.07 to 3.00; P = .028) progressed to dementia more rapidly than noncarriers.DiscussionGBA variants are of great clinical relevance for the development of dementia in Parkinson's disease, especially due to the relatively higher frequency of these alleles compared with other risk alleles.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Parkinson's Disease
- genetik
- Genetics
- neurologi
- Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lunde, Kristin A ...
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Chung, Janete
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Dalen, Ingvild
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Pedersen, Kenn F ...
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Linder, Jan
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Domellöf, Magdal ...
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show more...
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Elgh, Eva
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Macleod, Agnus D
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Tzoulis, Charala ...
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Larsen, Jan-Pett ...
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Tysnen, Ole-Bjør ...
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Forsgren, Lars
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Counsell, Carl E ...
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Alves, Guido
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Maple-Grødem, Jo ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Alzheimer's & De ...
- By the university
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Umeå University