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Facile Chemoenzymat...
Facile Chemoenzymatic Synthesis of O-Mannosyl Glycans
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Shuaishuai, Wang (author)
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Qing, Zhang (author)
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CongCong, Chen (author)
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Yuxi, Guo (author)
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Reddy, Gadi Madhusudhan (author)
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Jin, Yu (author)
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- Ulrika, Westerlind (author)
- Umeå universitet,Kemiska institutionen
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Yunpeng, Liu (author)
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Xuefeng, Cao (author)
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G., Wang Peng (author)
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Lei, Li (author)
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(creator_code:org_t)
- 2018-05-18
- 2018
- English.
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In: Angewandte Chemie International Edition. - : Wiley-VCH Verlagsgesellschaft. - 1433-7851 .- 1521-3773. ; 57:30, s. 9268-9273
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Abstract O?Mannosylation is a vital protein modification involved in brain and muscle development whereas the biological relevance of O-mannosyl glycans has remained largely unknown owing to the lack of structurally defined glycoforms. An efficient scaffold synthesis/enzymatic extension (SSEE) strategy was developed to prepare such structures by combining gram-scale convergent chemical syntheses of three scaffolds and strictly controlled sequential enzymatic extension catalyzed by glycosyltransferases. In total, 45 O-mannosyl glycans were obtained, covering the majority of identified mammalian structures. Subsequent glycan microarray analysis revealed fine specificities of glycan-binding proteins and specific antisera.
Subject headings
- NATURVETENSKAP -- Kemi -- Annan kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Other Chemistry Topics (hsv//eng)
Keyword
- carbohydrates
- chemoenzymatic synthesis
- glycosylation
- microarrays
- O-mannosyl glycans
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Shuaishuai, Wang
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Qing, Zhang
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CongCong, Chen
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Yuxi, Guo
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Reddy, Gadi Madh ...
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Jin, Yu
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show more...
-
Ulrika, Westerli ...
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Yunpeng, Liu
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Xuefeng, Cao
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G., Wang Peng
-
Lei, Li
-
show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Other Chemistry ...
- Articles in the publication
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Angewandte Chemi ...
- By the university
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Umeå University