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No association betw...
No association between circulating concentrations of vitamin D and risk of lung cancer : an analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3)
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Muller, D. C. (author)
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Hodge, A. M. (author)
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Fanidi, A. (author)
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show more...
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Albanes, D. (author)
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Mai, X. M. (author)
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Shu, X. O. (author)
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Weinstein, S. J. (author)
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Larose, T. L. (author)
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Zhang, X. (author)
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Han, J. (author)
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Stampfer, M. J. (author)
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Smith-Warner, S. A. (author)
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Ma, J. (author)
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Gaziano, J. M. (author)
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Sesso, H. D. (author)
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Stevens, V. L. (author)
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McCullough, M. L. (author)
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Layne, T. M. (author)
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Prentice, R. (author)
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Pettinger, M. (author)
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Thomson, C. A. (author)
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Zheng, W. (author)
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Gao, Y. T. (author)
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Rothman, N. (author)
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Xiang, Y. B. (author)
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Cai, H. (author)
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Wang, R. (author)
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Yuan, J. M. (author)
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Koh, W. P. (author)
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Butler, L. M. (author)
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Cai, Q. (author)
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Blot, W. J. (author)
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Wu, J. (author)
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Ueland, P. M. (author)
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Midttun, O. (author)
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Langhammer, A. (author)
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Hveem, K. (author)
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- Johansson, M. (author)
- Umeå universitet,Onkologi
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- Hultdin, Johan (author)
- Umeå universitet,Klinisk kemi
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- Grankvist, Kjell (author)
- Umeå universitet,Klinisk kemi
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Arslan, A. A. (author)
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Le Marchand, L. (author)
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Severi, G. (author)
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Brennan, P. (author)
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(creator_code:org_t)
- Oxford University Press, 2018
- 2018
- English.
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In: Annals of Oncology. - : Oxford University Press. - 0923-7534 .- 1569-8041. ; 29:6, s. 1468-1475
- Related links:
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http://www.annalsofo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: There is observational evidence suggesting that high vitamin D concentrations may protect against lung cancer. To investigate this hypothesis in detail, we measured circulating vitamin D concentrations in prediagnostic blood from 20 cohorts participating in the Lung Cancer Cohort Consortium (LC3).Patients and methods: The study included 5313 lung cancer cases and 5313 controls. Blood samples for the cases were collected, on average, 5 years before lung cancer diagnosis. Controls were individually matched to the cases by cohort, sex, age, race/ethnicity, date of blood collection, and smoking status in five categories. Liquid chromatography coupled with tandem mass spectrometry was used to separately analyze 25-hydroxyvitamin D2 [25(OH)D2] and 25-hydroxyvitamin D3 [25(OH)D3] and their concentrations were combined to give an overall measure of 25(OH)D. We used conditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for 25(OH)D as both continuous and categorical variables.Results: Overall, no apparent association between 25(OH)D and risk of lung cancer was observed (multivariable adjusted OR for a doubling in concentration: 0.98, 95% CI: 0.91, 1.06). Similarly, we found no clear evidence of interaction by cohort, sex, age, smoking status, or histology.Conclusion: This study did not support an association between vitamin D concentrations and lung cancer risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- serum 25-hydroxyvitamin D
- vitamin D
- lung cancer
- case control
- prospective
- consortium
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Muller, D. C.
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Hodge, A. M.
-
Fanidi, A.
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Albanes, D.
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Mai, X. M.
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Shu, X. O.
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show more...
-
Weinstein, S. J.
-
Larose, T. L.
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Zhang, X.
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Han, J.
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Stampfer, M. J.
-
Smith-Warner, S. ...
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Ma, J.
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Gaziano, J. M.
-
Sesso, H. D.
-
Stevens, V. L.
-
McCullough, M. L ...
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Layne, T. M.
-
Prentice, R.
-
Pettinger, M.
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Thomson, C. A.
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Zheng, W.
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Gao, Y. T.
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Rothman, N.
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Xiang, Y. B.
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Cai, H.
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Wang, R.
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Yuan, J. M.
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Koh, W. P.
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Butler, L. M.
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Cai, Q.
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Blot, W. J.
-
Wu, J.
-
Ueland, P. M.
-
Midttun, O.
-
Langhammer, A.
-
Hveem, K.
-
Johansson, M.
-
Hultdin, Johan
-
Grankvist, Kjell
-
Arslan, A. A.
-
Le Marchand, L.
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Severi, G.
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Brennan, P.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Annals of Oncolo ...
- By the university
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Umeå University