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- Mandel, AnnaUmeå University,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten) (author)
The interplay between AR, EGF receptor and MMP-9 signaling pathways in invasive prostate cancer
- Article/chapterEnglish2018
Publisher, publication year, extent ...
- 2018-06-27
- Springer,2018
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-150769
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-150769URI
- https://doi.org/10.1186/s10020-018-0035-4DOI
- https://lup.lub.lu.se/record/9473913f-5dc9-45d9-96a9-a80036e946b1URI
Supplementary language notes
- Language:English
- Summary in:English
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- Background: Metastatic Prostate cancer (PCa) cells have gained survival and invasive advantages. Epidermal growth factor (EGA) receptor is a receptor tyrosine kinase, which may mediate signalling to promote progression and invasion of various cancers. In this study, we uncovered the molecular mechanisms underlying the interconnection among the androgen receptor (AR), matrix metalloproteinase-9 (MMP9) and EGFR in promoting PCa progression. Methods: Immunohistochemical analysis of the tissue microarrays consisting of primary and metastatic PCa tissues was performed. The clinical importance of EGFR and its association with survivals were analyzed using three cohorts from MSKCC Prostate Oncogenome Project dataset (For primary tumors, n = 181; for metastatic tumors n = 37) and The Cancer Genome Atlas Prostate Adenocarcinoma Provisional dataset (n = 495). Targeted overexpression or inhibition of the proteins of interests was introduced into PCa cell lines. Treatment of PCa cell lines with the compounds was conducted. Immunoblot analysis was performed. Results: We showed that AR, MMP-9 and EGFR are interconnect factors, which may cooperatively promote PCa progression. Altered EGFR expression was associated with poor disease-free survival in PCa patients. Induced overexpression of AR led to an increase in the expression of EGFR, p-GSK-313 and decrease in p27 expression in PCa cell lines in the presence of androgen stimulation. Overexpression of MMP9 significantly induced EGFR expression in PCa cells. Inhibition of PIP5K1a, a lipid kinase that acts upstream of PI3K/AKT greatly reduced expressions of AR, MMP-9 and EGFR. Conclusions: Our findings also suggest that PCa cells may utilize AR, EGFR and MMP-9 pathways in androgen-dependent as well as in castration-resistant conditions. Our data suggest a new therapeutic potential to block cancer metastasis by targeting AR, EGFR and MMP-9 pathways in subsets of PCa patients.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi Medicinsk bioteknologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Medical Biotechnology Medical Biotechnology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine hsv//eng
- Prostate cancer
- Cancer metastasis
- Epidermal growth factor receptor
- Androgen receptor and androgen
Added entries (persons, corporate bodies, meetings, titles ...)
- Larsson, PerUmeå University,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten) (author)
- Sarwar, MartuzaLund University,Lunds universitet,Experimentell cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Experimental Cancer Research, Malmö,Lund University Research Groups(Swepub:lu)med-mzs (author)
- Semenas, JuliusUmeå University,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)(Swepub:umu)juse0005 (author)
- Khaja, Azharuddin Sajid SyedUmeå University,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten) (author)
- Persson, Jenny L.Umeå University,Lund University,Lunds universitet,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Experimentell cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Experimental Cancer Research, Malmö,Lund University Research Groups(Swepub:lu)medk-jpe (author)
- Umeå universitetInstitutionen för molekylärbiologi (Medicinska fakulteten) (creator_code:org_t)
Related titles
- In:Molecular Medicine: Springer24, s. 1-131076-15511528-3658
Internet link
- https://doi.org/10.1186/s10020-018-0035-4Fulltext
- https://umu.diva-portal.org/smash/get/diva2:1244388/FULLTEXT01.pdffulltext:print
- https://molmed.biomedcentral.com/track/pdf/10.1186/s10020-018-0035-4
- http://dx.doi.org/10.1186/s10020-018-0035-4FULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-150769
- https://doi.org/10.1186/s10020-018-0035-4
- https://lup.lub.lu.se/record/9473913f-5dc9-45d9-96a9-a80036e946b1
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