onr:"swepub:oai:DiVA.org:umu-150769"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05273naa a2200505 4500 | |
| 001 | oai:DiVA.org:umu-150769 | |
| 003 | SwePub | |
| 008 | 180831s2018 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:9473913f-5dc9-45d9-96a9-a80036e946b1 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1507692 URI |
| 024 | 7 | a https://doi.org/10.1186/s10020-018-0035-42 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/9473913f-5dc9-45d9-96a9-a80036e946b12 URI |
| 040 | a (SwePub)umud (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Mandel, Annau Umeå University,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)4 aut0 (Swepub:umu)anma0626 |
| 245 | 1 0 | a The interplay between AR, EGF receptor and MMP-9 signaling pathways in invasive prostate cancer |
| 264 | c 2018-06-27 | |
| 264 | 1 | b Springer,c 2018 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Background: Metastatic Prostate cancer (PCa) cells have gained survival and invasive advantages. Epidermal growth factor (EGA) receptor is a receptor tyrosine kinase, which may mediate signalling to promote progression and invasion of various cancers. In this study, we uncovered the molecular mechanisms underlying the interconnection among the androgen receptor (AR), matrix metalloproteinase-9 (MMP9) and EGFR in promoting PCa progression. Methods: Immunohistochemical analysis of the tissue microarrays consisting of primary and metastatic PCa tissues was performed. The clinical importance of EGFR and its association with survivals were analyzed using three cohorts from MSKCC Prostate Oncogenome Project dataset (For primary tumors, n = 181; for metastatic tumors n = 37) and The Cancer Genome Atlas Prostate Adenocarcinoma Provisional dataset (n = 495). Targeted overexpression or inhibition of the proteins of interests was introduced into PCa cell lines. Treatment of PCa cell lines with the compounds was conducted. Immunoblot analysis was performed. Results: We showed that AR, MMP-9 and EGFR are interconnect factors, which may cooperatively promote PCa progression. Altered EGFR expression was associated with poor disease-free survival in PCa patients. Induced overexpression of AR led to an increase in the expression of EGFR, p-GSK-313 and decrease in p27 expression in PCa cell lines in the presence of androgen stimulation. Overexpression of MMP9 significantly induced EGFR expression in PCa cells. Inhibition of PIP5K1a, a lipid kinase that acts upstream of PI3K/AKT greatly reduced expressions of AR, MMP-9 and EGFR. Conclusions: Our findings also suggest that PCa cells may utilize AR, EGFR and MMP-9 pathways in androgen-dependent as well as in castration-resistant conditions. Our data suggest a new therapeutic potential to block cancer metastasis by targeting AR, EGFR and MMP-9 pathways in subsets of PCa patients. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaper0 (SwePub)3012 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicine0 (SwePub)3012 hsv//eng |
| 653 | a Prostate cancer | |
| 653 | a Cancer metastasis | |
| 653 | a Epidermal growth factor receptor | |
| 653 | a Androgen receptor and androgen | |
| 700 | 1 | a Larsson, Peru Umeå University,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)4 aut |
| 700 | 1 | a Sarwar, Martuzau Lund University,Lunds universitet,Experimentell cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Experimental Cancer Research, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)med-mzs |
| 700 | 1 | a Semenas, Juliusu Umeå University,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)4 aut0 (Swepub:umu)juse0005 |
| 700 | 1 | a Khaja, Azharuddin Sajid Syedu Umeå University,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)4 aut |
| 700 | 1 | a Persson, Jenny L.u Umeå University,Lund University,Lunds universitet,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Experimentell cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Experimental Cancer Research, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)medk-jpe |
| 710 | 2 | a Umeå universitetb Institutionen för molekylärbiologi (Medicinska fakulteten)4 org |
| 773 | 0 | t Molecular Medicined : Springerg 24, s. 1-13q 24<1-13x 1076-1551x 1528-3658 |
| 856 | 4 | u https://doi.org/10.1186/s10020-018-0035-4y Fulltext |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1244388/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://molmed.biomedcentral.com/track/pdf/10.1186/s10020-018-0035-4 |
| 856 | 4 | u http://dx.doi.org/10.1186/s10020-018-0035-4x freey FULLTEXT |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-150769 |
| 856 | 4 8 | u https://doi.org/10.1186/s10020-018-0035-4 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/9473913f-5dc9-45d9-96a9-a80036e946b1 |
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