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Exposure to an anti...
Exposure to an anti-androgenic herbicide negatively impacts reproductive physiology and fertility in Xenopustropicalis
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- Orton, F. (author)
- Univ West Scotland, Sch Sci & Sport, Paisley, Renfrew, Scotland
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- Säfholm, Moa (author)
- Uppsala universitet,Miljötoxikologi
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- Jansson, Erika (author)
- Uppsala universitet,Miljötoxikologi
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- Carlsson, Y. (author)
- Uppsala universitet,Miljötoxikologi
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- Eriksson, A. (author)
- Uppsala universitet,Miljötoxikologi
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- Fick, Jerker (author)
- Umeå universitet,Kemiska institutionen,Umea Univ, Dept Chem, Umea, Sweden
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- Webster, T. Uren (author)
- Swansea Univ, Swansea, W Glam, Wales
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- McMillan, T. (author)
- Univ West Scotland, Sch Sci & Sport, Paisley, Renfrew, Scotland
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- Leishman, M. (author)
- Univ West Scotland, Sch Sci & Sport, Paisley, Renfrew, Scotland
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- Verbruggen, B. (author)
- Univ Exeter, Coll Life & Environm Sci, Exeter, Devon, England
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- Economou, T. (author)
- Univ Exeter, Coll Life & Environm Sci, Exeter, Devon, England
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- Tyler, C. R. (author)
- Univ Exeter, Coll Life & Environm Sci, Exeter, Devon, England
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- Berg, Cecilia, 1967- (author)
- Uppsala universitet,Miljötoxikologi
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(creator_code:org_t)
- 2018-06-14
- 2018
- English.
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In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 8
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Abstract
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- Amphibians are threatened on a global scale and pollutants may be contributing to population declines, but how chemicals impact on their reproduction is poorly understood. We conducted a life cycle analysis to investigate the impacts of early life exposure to two anti-androgens (exposure until completion of metamorphosis;stage 66): flutamide, (50 µg/L)/linuron (9 and 45 µg/L)) on sexual development and breeding competence in Xenopus tropicalis. Our analyses included: mRNA levels of dmrt1, cyp17, amh, cyp19, foxl2 and ar (tadpoles/metamorphs), gonadal histomorphology (metamorphs/adults), mRNA levels of ar/gr (adult male brain/gonad/forelimb), testosterone/corticosterone levels (adult males), secondary sexual characteristics (forelimb width/nuptial pad: adult males) and breeding competence (amplexus/fertility: adult males). Compared to controls, feminised sex ratios and increased number of spermatogonia (adults) were observed after exposure to flutamide and the lower linuron concentration. Exposure to the lower linuron concentration also resulted in demasculinisation of secondary sexual characteristics and reduced male fertility. Flutamide exposure resulted in masculinisation of the nuptial pad and elevated mRNA levels of dmrt1, cyp17, amh and foxl2 in brains (metamorphs). Testosterone levels were higher in all treatment groups, however, overall few effects were observed in response to the higher linuron concentration. Our findings advance understanding of reproductive biology of X. tropicalis and illustrate negative effects of linuron on reproductive processes at a concentration measured in freshwater environments.
Subject headings
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Ekologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Ecology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Orton, F.
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Säfholm, Moa
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Jansson, Erika
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Carlsson, Y.
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Eriksson, A.
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Fick, Jerker
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show more...
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Webster, T. Uren
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McMillan, T.
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Leishman, M.
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Verbruggen, B.
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Economou, T.
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Tyler, C. R.
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Berg, Cecilia, 1 ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Earth and Relate ...
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and Environmental Sc ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Ecology
- Articles in the publication
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Scientific Repor ...
- By the university
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Umeå University
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Uppsala University