Search: onr:"swepub:oai:DiVA.org:umu-150859" >
Germline variants i...
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FitzGerald, L. M.Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic 3004, Australia;Univ Tasmania, Menzies Inst Med Res, Canc Genet & Immunol, Hobart, Tas 7001, Australia
(author)
Germline variants in IL4, MGMT and AKT1 are associated with prostate cancer-specific mortality : an analysis of 12,082 prostate cancer cases
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-01-03
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Nature Publishing Group,2018
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-150859
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-150859URI
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https://doi.org/10.1038/s41391-017-0029-2DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-360483URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:138690424URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background Prostate cancer (PCa) is a leading cause of mortality and genetic factors can influence tumour aggressiveness. Several germline variants have been associated with PCa-specific mortality (PCSM), but further replication evidence is needed. Methods Twenty-two previously identified PCSM-associated genetic variants were genotyped in seven PCa cohorts (12,082 patients; 1544 PCa deaths). For each cohort, Cox proportional hazards models were used to calculate hazard ratios and 95% confidence intervals for risk of PCSM associated with each variant. Data were then combined using a meta-analysis approach. Results Fifteen SNPs were associated with PCSM in at least one of the seven cohorts. In the meta-analysis, after adjustment for clinicopathological factors, variants in the MGMT (rs2308327; HR 0.90; p-value = 3.5 x 10(-2)) and IL4 (rs2070874; HR 1.22; p-value = 1.1 x 10(-3)) genes were confirmed to be associated with risk of PCSM. In analyses limited to men diagnosed with local or regional stage disease, a variant in AKT1, rs2494750, was also confirmed to be associated with PCSM risk (HR 0.81; p-value = 3.6 x 10(-2)). Conclusions This meta-analysis confirms the association of three genetic variants with risk of PCSM, providing further evidence that genetic background plays a role in PCa-specific survival. While these variants alone are not sufficient as prognostic biomarkers, these results may provide insights into the biological pathways modulating tumour aggressiveness.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Zhao, S.NIEHS, Biostat & Computat Biol Branch, Res Triangle Pk, NC 27709 USA
(author)
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Leonardson, A.Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA
(author)
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Geybels, M. S.Maastricht Univ, Med Ctr, GROW Sch Oncol & Dev Biol, Dept Epidemiol, NL-6211 LK Maastricht, Netherlands;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA
(author)
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Kolb, S.Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA
(author)
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Lin, D. W.Univ Washington, Sch Med, Dept Urol, Seattle, WA 98195 USA;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA
(author)
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Wright, J. L.Univ Washington, Sch Med, Dept Urol, Seattle, WA 98195 USA;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA
(author)
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Eeles, R.Royal Marsden Natl Hlth Serv Fdn Trust, London, England;Royal Marsden Natl Hlth Serv Fdn Trust, Sutton SW3 6JJ, Surrey, England;Inst Canc Res, Sutton SM2 5NG, Surrey, England
(author)
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Kote-Jarai, Z.Inst Canc Res, Sutton SM2 5NG, Surrey, England
(author)
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Govindasami, K.Inst Canc Res, Sutton SM2 5NG, Surrey, England
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Giles, G. G.Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Carlton, Vic 3053, Australia;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic 3004, Australia
(author)
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Southey, M. C.Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Parkville, Vic 3010, Australia
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Schleutker, J.Turku Univ Hosp, Dept Med Genet, Tuch Microbiol & Genet, Turku 20520, Finland;Univ Turku, Dept Med Biochem & Genet, Inst Biomed, Turku 20014, Finland
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Tammela, T. L.Tampere Univ Hosp, Dept Urol, Tampere 33521, Finland;Univ Tampere, Prostate Canc Res Ctr, Sch Med, Tampere 33100, Finland
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Sipeky, C.Univ Turku, Dept Med Biochem & Genet, Inst Biomed, Turku 20014, Finland
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Penney, K. L.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA;Brigham & Womens Hosp, Dept Med, Charming Div Network Med, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA
(author)
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Stampfer, M. J.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA;Brigham & Womens Hosp, Dept Med, Charming Div Network Med, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
(author)
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Gronberg, H.Karolinska Institutet
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Wiklund, F.Karolinska Institutet
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Stattin, P.Uppsala universitet,Umeå universitet,Urologi och andrologi,Urologkirurgi,Umea Univ, Dept Surg & Perioperat Sci, S-90187 Umea, Sweden(Swepub:uu)parst892
(author)
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Hugosson, J.Univ Goteborgs, Inst Clin Sci, Dept Urol, S-40530 Goteborgs, Sweden
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Karyadi, D. M.NHGRI, NIH, Bethesda, MD 20854 USA
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Ostrander, E. A.NHGRI, NIH, Bethesda, MD 20854 USA
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Feng, Z.MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA
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Stanford, J. L.Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA
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Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic 3004, Australia;Univ Tasmania, Menzies Inst Med Res, Canc Genet & Immunol, Hobart, Tas 7001, AustraliaNIEHS, Biostat & Computat Biol Branch, Res Triangle Pk, NC 27709 USA
(creator_code:org_t)
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In:Prostate Cancer and Prostatic Diseases: Nature Publishing Group21:2, s. 228-2371365-78521476-5608
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FitzGerald, L. M ...
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Zhao, S.
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Leonardson, A.
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Geybels, M. S.
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Kolb, S.
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Lin, D. W.
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show more...
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Wright, J. L.
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Eeles, R.
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Kote-Jarai, Z.
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Govindasami, K.
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Giles, G. G.
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Southey, M. C.
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Schleutker, J.
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Tammela, T. L.
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Sipeky, C.
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Penney, K. L.
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Stampfer, M. J.
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Gronberg, H.
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Wiklund, F.
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Stattin, P.
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Hugosson, J.
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Karyadi, D. M.
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Ostrander, E. A.
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Feng, Z.
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Stanford, J. L.
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Prostate Cancer ...
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Umeå University
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Uppsala University
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Karolinska Institutet