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Prognostic scoring ...
Prognostic scoring systems for myelodysplastic syndromes (MDS) in a population-based setting : a report from the Swedish MDS register
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- Berggren, Daniel Moreno (author)
- Uppsala universitet,Hematologi
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- Folkvaljon, Yasin (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper
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- Engvall, Marie (author)
- Uppsala universitet,Medicinsk genetik och genomik
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- Sundberg, Johan (author)
- Uppsala universitet,Hematologi
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- Lambe, Mats (author)
- Uppsala universitet,Karolinska Institutet,Uppsala Univ Hosp, Sweden; Karolinska Inst, Sweden,Institutionen för kirurgiska vetenskaper,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
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- Antunovic, Petar (author)
- Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US,Linkoping Univ Hosp, Dept Haematol, Linkoping, Sweden
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- Garelius, Hege (author)
- Section for Haematology and Coagulation, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Sect Haematol & Coagulat, Dept Med, Gothenburg, Sweden
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- Lorenz, Fryderyk (author)
- Umeå universitet,Onkologi,Department of Medical Biosciences, Umeå University, Umeå, Sweden,Umea Univ, Dept Med Biosci, Umea, Sweden
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- Nilsson, Lars (author)
- Department of Haematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden,Skane Univ Hosp, Dept Haematol Oncol & Radiat Phys, Lund, Sweden
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- Rasmussen, Bengt, 1970- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ Hosp, Sch Med Sci, Orebro, Sweden
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- Lehmann, Sören (author)
- Uppsala universitet,Karolinska Institutet,Uppsala Univ, Sweden,Hematologi
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- Hellström-Lindberg, Eva (author)
- Karolinska Institutet,Karolinska Inst, Karolinska Univ Hosp, Dept Med Huddinge, Ctr Haematol & Regenerat Med, Stockholm, Sweden
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- Jädersten, Martin (author)
- Karolinska Institutet,Karolinska Inst, Karolinska Univ Hosp, Dept Med Huddinge, Ctr Haematol & Regenerat Med, Stockholm, Sweden
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- Ejerblad, Elisabeth (author)
- Uppsala universitet,Hematologi
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(creator_code:org_t)
- 2018-04-29
- 2018
- English.
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In: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 181:5, s. 614-627
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Abstract
Subject headings
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- The myelodysplastic syndromes (MDS) have highly variable outcomes and prognostic scoring systems are important tools for risk assessment and to guide therapeutic decisions. However, few population-based studies have compared the value of the different scoring systems. With data from the nationwide Swedish population-based MDS register we validated the International Prognostic Scoring System (IPSS), revised IPSS (IPSS-R) and the World Health Organization (WHO) Classification-based Prognostic Scoring System (WPSS). We also present population-based data on incidence, clinical characteristics including detailed cytogenetics and outcome from the register. The study encompassed 1329 patients reported to the register between 2009 and 2013, 14% of these had therapy-related MDS (t-MDS). Based on the MDS register, the yearly crude incidence of MDS in Sweden was 2.9 per 100000 inhabitants. IPSS-R had a significantly better prognostic power than IPSS (P < 0001). There was a trend for better prognostic power of IPSS-R compared to WPSS (P=0.05) and for WPSS compared to IPSS (P=0.07). IPSS-R was superior to both IPSS and WPSS for patients aged <= 70years. Patients with t-MDS had a worse outcome compared to de novo MDS (d-MDS), however, the validity of the prognostic scoring systems was comparable for d-MDS and t-MDS. In conclusion, population-based studies are important to validate prognostic scores in a real-world' setting. In our nationwide cohort, the IPSS-R showed the best predictive power.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- myelodysplastic syndrome
- International Prognostic Scoring System
- revised International Prognostic Scoring System
- WHO Classification-based Prognostic Scoring System
- therapy-related myelodysplastic syndrome
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Berggren, Daniel ...
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Folkvaljon, Yasi ...
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Engvall, Marie
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Sundberg, Johan
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Lambe, Mats
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Antunovic, Petar
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show more...
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Garelius, Hege
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Lorenz, Fryderyk
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Nilsson, Lars
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Rasmussen, Bengt ...
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Lehmann, Sören
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Hellström-Lindbe ...
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Jädersten, Marti ...
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Ejerblad, Elisab ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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British Journal ...
- By the university
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Umeå University
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Örebro University
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Karolinska Institutet
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Linköping University
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Uppsala University