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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03535naa a2200613 4500 | |
| 001 | oai:DiVA.org:umu-150962 | |
| 003 | SwePub | |
| 008 | 180821s2018 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1509622 URI |
| 024 | 7 | a https://doi.org/10.15252/embj.2018991542 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Li, Shuqi4 aut |
| 245 | 1 0 | a Rtt105 functions as a chaperone for replication protein A to preserve genome stability |
| 264 | c 2018-07-31 | |
| 264 | 1 | b Wiley-VCH Verlagsgesellschaft,c 2018 |
| 338 | a print2 rdacarrier | |
| 520 | a Generation of single-stranded DNA (ssDNA) is required for the template strand formation during DNA replication. Replication Protein A (RPA) is an ssDNA-binding protein essential for protecting ssDNA at replication forks in eukaryotic cells. While significant progress has been made in characterizing the role of the RPA-ssDNA complex, how RPA is loaded at replication forks remains poorly explored. Here, we show that the Saccharomyces cerevisiae protein regulator of Ty1 transposition 105 (Rtt105) binds RPA and helps load it at replication forks. Cells lacking Rtt105 exhibit a dramatic reduction in RPA loading at replication forks, compromised DNA synthesis under replication stress, and increased genome instability. Mechanistically, we show that Rtt105 mediates the RPA-importin interaction and also promotes RPA binding to ssDNA directly in vitro, but is not present in the final RPA-ssDNA complex. Single-molecule studies reveal that Rtt105 affects the binding mode of RPA to ssDNA These results support a model in which Rtt105 functions as an RPA chaperone that escorts RPA to the nucleus and facilitates its loading onto ssDNA at replication forks. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 653 | a RPA chaperone | |
| 653 | a Rtt105 | |
| 653 | a replication fork | |
| 653 | a replication stress | |
| 700 | 1 | a Xu, Zhiyun4 aut |
| 700 | 1 | a Xu, Jiawei4 aut |
| 700 | 1 | a Zuo, Linyu4 aut |
| 700 | 1 | a Yu, Chuanhe4 aut |
| 700 | 1 | a Zheng, Pu4 aut |
| 700 | 1 | a Gan, Haiyun4 aut |
| 700 | 1 | a Wang, Xuezheng4 aut |
| 700 | 1 | a Li, Longtu4 aut |
| 700 | 1 | a Sharma, Sushmau Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut0 (Swepub:umu)sush0003 |
| 700 | 1 | a Chabes, Andreiu Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut0 (Swepub:umu)anch0002 |
| 700 | 1 | a Li, Di4 aut |
| 700 | 1 | a Wang, Sheng4 aut |
| 700 | 1 | a Zheng, Sihao4 aut |
| 700 | 1 | a Li, Jinbao4 aut |
| 700 | 1 | a Chen, Xuefeng4 aut |
| 700 | 1 | a Sun, Yujie4 aut |
| 700 | 1 | a Xu, Dongyi4 aut |
| 700 | 1 | a Han, Junhong4 aut |
| 700 | 1 | a Chan, Kuiming4 aut |
| 700 | 1 | a Qi, Zhi4 aut |
| 700 | 1 | a Feng, Jianxun4 aut |
| 700 | 1 | a Li, Qing4 aut |
| 710 | 2 | a Umeå universitetb Institutionen för medicinsk kemi och biofysik4 org |
| 773 | 0 | t EMBO Journald : Wiley-VCH Verlagsgesellschaftg 37:17q 37:17x 0261-4189x 1460-2075 |
| 856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.201899154 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-150962 |
| 856 | 4 8 | u https://doi.org/10.15252/embj.201899154 |
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