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An international su...
An international survey on anti-neutrophil cytoplasmic antibodies (ANCA) testing in daily clinical practice
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Damoiseaux, Jan (author)
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Heijnen, Ingmar (author)
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Van Campenhout, Christel (author)
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- Eriksson, Catharina, 1955- (author)
- Umeå universitet,Immunologi/immunkemi
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Fabien, Nicole (author)
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Herold, Manfred (author)
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van der Molen, Renate G. (author)
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Egner, William (author)
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Patel, Dina (author)
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Plaza-Lopez, Aresio (author)
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Radice, Antonella (author)
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Rego de Sousa, Marie Jose (author)
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Viander, Markku (author)
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Shoenfeld, Yehuda (author)
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(creator_code:org_t)
- 2017-07-15
- 2018
- English.
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In: Clinical Chemistry and Laboratory Medicine. - : Walter de Gruyter. - 1434-6621 .- 1437-4331. ; 56:10, s. 1759-1770
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http://eprints.white...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Detection of anti-neutrophil cytoplasmic antibodies (ANCA) is important for the diagnosis of the ANCA-associated vasculitides (AAV). For AAV, especially ANCA directed against myeloperoxidase (MPO) and proteinase 3 (PR3) are most relevant. ANCA with less well-defined specificities may, however, also be detected in other inflammatory and non-inflammatory conditions.Methods: A questionnaire, initiated by the European Autoimmunity Standardisation Initiative (EASI), was used to gather information on methods and testing algorithms used for ANCA in clinical laboratories of 12 European countries (EASI survey).Results: Four hundred and twenty-nine responses were included in the EASI survey analysis which revealed differences within countries and between countries. Laboratories overall were poor in adherence to international consensus on ANCA testing. Substantial variation was observed with respect to the use of ANCA indirect immunofluorescence (IIF) in the algorithm, application of distinct methods for MPO- and PR3-ANCA, the daily availability of new ANCA results, and interpretation of test results.Conclusions: Awareness of these differences may stimulate further harmonization and standardization of ANCA testing. This may be promoted by an update of the international ANCA consensus and the introduction of international standards.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- ANCA
- myeloperoxidase
- proteinase-3
- testing algorithm
- vasculitis
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Damoiseaux, Jan
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Heijnen, Ingmar
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Van Campenhout, ...
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Eriksson, Cathar ...
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Fabien, Nicole
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Herold, Manfred
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van der Molen, R ...
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Egner, William
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Patel, Dina
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Plaza-Lopez, Are ...
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Radice, Antonell ...
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Rego de Sousa, M ...
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Viander, Markku
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Shoenfeld, Yehud ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
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Clinical Chemist ...
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Umeå University