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Defective induction...
Defective induction of CTLA-4 in the NOD mouse is controlled by the NOD allele of Idd3/IL-2 and a novel locus (Ctex) telomeric on chromosome 1
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- Lundholm, Marie, 1974- (author)
- Umeå universitet,Medicinsk och klinisk genetik
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- Motta, Vinicius (author)
- Umeå universitet,Medicinsk och klinisk genetik
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- Löfgren-Burström, Anna (author)
- Umeå universitet,Medicinsk och klinisk genetik
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- Duarte, Nadia (author)
- Umeå universitet,Medicinsk och klinisk genetik
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- Bergman, Marie-Louise (author)
- Umeå universitet,Medicinsk och klinisk genetik
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- Mayans, Sofia (author)
- Umeå universitet,Medicinsk och klinisk genetik
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- Holmberg, Dan (author)
- Umeå universitet,Medicinsk och klinisk genetik
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(creator_code:org_t)
- American Diabetes Association, 2006
- 2006
- English.
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In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 55:2, s. 538-544
- Related links:
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http://diabetes.diab...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Subject headings
Close
- Cytotoxic T-lymphocyte–associated antigen-4 (CTLA-4), or CD152, is a negative regulator of T-cell activation and has been shown to be associated with autoimmune diseases. Previous work has demonstrated a defect in the expression of this molecule in nonobese diabetic (NOD) mice upon anti-CD3 stimulation in vitro. Using a genetic approach we here demonstrate that a novel locus (Ctex) telomeric on chromosome 1 together with the Idd3 (Il-2) gene confers optimal CTLA-4 expression upon CD3 activation of T-cells. Based on these data, we provide a model for how gene interaction between Idd3 (IL-2), Ctex, and Idd5.1 (Ctla-4) could confer susceptibility to autoimmune diabetes in the NOD mouse. Additionally, we showed that the Ctex and the Idd3 regions do not influence inducible T-cell costimulator (ICOS) protein expression in NOD mice. Instead, as previously shown, higher ICOS levels in NOD mice appear to be controlled by gene(s) in the Idd5.1 region, possibly a polymorphism in the Icos gene itself.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Alleles
- Animals
- Antigens; CD
- Antigens; Differentiation/genetics/*metabolism
- Cells; Cultured
- Chromosomes; Mammalian/*genetics
- Diabetes Mellitus/*genetics
- Female
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Genotype
- Interleukin-2/*genetics
- Mice
- Mice; Inbred C57BL
- Mice; Inbred NOD
- Physical Chromosome Mapping
- Spleen/cytology
- Telomere/*genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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