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Neutralizing Antibo...
Neutralizing Antibodies Inhibit Chikungunya Virus Budding at the Plasma Membrane
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Jin, Jing (author)
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Galaz-Montoya, Jesus G. (author)
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Sherman, Michael B. (author)
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Sun, Stella Y. (author)
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Goldsmith, Cynthia S. (author)
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O'Toole, Eileen T. (author)
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Ackerman, Larry (author)
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- Carlson, Lars-Anders (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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Weaver, Scott C. (author)
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Chiu, Wah (author)
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Simmons, Graham (author)
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(creator_code:org_t)
- Cell Press, 2018
- 2018
- English.
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In: Cell Host and Microbe. - : Cell Press. - 1931-3128 .- 1934-6069. ; 24:3, s. 417-
- Related links:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Neutralizing antibodies (NAbs) are traditionally thought to inhibit virus infection by preventing virion entry into target cells. In addition, antibodies can engage Fc receptors (FcRs) on immune cells to activate antiviral responses. We describe a mechanism by which NAbs inhibit chikungunya virus (CHIKV), the most common alphavirus infecting humans, by preventing virus budding from infected human cells and activating IgG-specific Fc gamma receptors. NAbs bind to CHIKV glycoproteins on the infected cell surface and induce glycoprotein coalescence, preventing budding of nascent virions and leaving structurally heterogeneous nucleocapsids arrested in the cytosol. Furthermore, NAbs induce clustering of CHIKV replication spherules at sites of budding blockage. Functionally, these densely packed glycoprotein-NAb complexes on infected cells activate Fc gamma receptors, inducing a strong, antibody-dependent, cell-mediated cytotoxicity response from immune effector cells. Our findings describe a triply functional antiviral pathway for NAbs that might be broadly applicable across virus-host systems, suggesting avenues for therapeutic innovation through antibody design.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Jin, Jing
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Galaz-Montoya, J ...
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Sherman, Michael ...
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Sun, Stella Y.
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Goldsmith, Cynth ...
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O'Toole, Eileen ...
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show more...
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Ackerman, Larry
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Carlson, Lars-An ...
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Weaver, Scott C.
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Chiu, Wah
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Simmons, Graham
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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Cell Host and Mi ...
- By the university
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Umeå University