Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity

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Ferreiro-Iglesias, AidaInternational Agency for Research on Cancer, World Health Organization (author)

Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity

Article/chapterEnglish2018

Publisher, publication year, extent ...

2018-09-25
Nature Publishing Group,2018
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-153722
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-153722URI
https://doi.org/10.1038/s41467-018-05890-2DOI
https://lup.lub.lu.se/record/76b70b44-2df4-423a-80aa-0b92fc13a828URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Lung cancer has several genetic associations identified within the major histocompatibility complex (MHC); although the basis for these associations remains elusive. Here, we analyze MHC genetic variation among 26,044 lung cancer patients and 20,836 controls densely genotyped across the MHC, using the Illumina Illumina OncoArray or Illumina 660W SNP microarray. We impute sequence variation in classical HLA genes, fine-map MHC associations for lung cancer risk with major histologies and compare results between ethnicities. Independent and novel associations within HLA genes are identified in Europeans including amino acids in the HLA-B*0801 peptide binding groove and an independent HLA-DQB1*06 loci group. In Asians, associations are driven by two independent HLA allele sets that both increase risk in HLA-DQB1*0401 and HLA-DRB1*0701; the latter better represented by the amino acid Ala-104. These results implicate several HLA-tumor peptide interactions as the major MHC factor modulating lung cancer susceptibility.

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Lesseur, CorinaInternational Agency for Research on Cancer, World Health Organization (author)
McKay, JamesInternational Agency for Research on Cancer, World Health Organization (author)
Hung, Rayjean J.University of Toronto (author)
Han, YounghunDartmouth College (author)
Zong, XuchenUniversity of Toronto (author)
Christiani, DavidMassachusetts General Hospital,Dartmouth College (author)
Johansson, MattiasInternational Agency for Research on Cancer, World Health Organization (author)
Xiao, XiangjunDartmouth College (author)
Li, YafangDartmouth College (author)
Qian, David C.University of Washington (author)
Ji, XuemeiDartmouth College (author)
Liu, GeoffreyUniversity of Toronto (author)
Caporaso, NeilNational Cancer Institute, USA (author)
Scelo, GhislaineInternational Agency for Research on Cancer, World Health Organization (author)
Zaridze, DavidN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences (author)
Mukeriya, AnushN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences (author)
Kontic, MilicaClinical Center of Serbia (author)
Ognjanovic, SimonaInternational Organization for Cancer Prevention and Research (author)
Lissowska, JolantaThe Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology (author)
Szolkowska, MalgorzataNational Tuberculosis and Lung Diseases Research Institute (author)
Swiatkowska, BeataNofer Institute of Occupational Medicine (author)
Janout, VladimirPalacký University (author)
Holcatova, IvanaCharles University in Prague (author)
Bolca, CiprianNational Institute of Pneumology M. Nasta (author)
Savic, MilanClinical Center of Serbia (author)
Ognjanovic, MiodragInternational Organization for Cancer Prevention and Research (author)
Bojesen, Stig EgilUniversity of Copenhagen,Gentofte Hospital (author)
Wu, XifengUniversity of Texas (author)
Albanes, DemetriosNational Cancer Institute, USA (author)
Aldrich, Melinda C.Vanderbilt University (author)
Tardon, AdoninaUniversity of Oviedo (author)
Fernandez-Somoano, AnaUniversity of Oviedo (author)
Fernandez-Tardon, GuillermoUniversity of Oviedo (author)
Le Marchand, LoicUniversity of Hawaii at Manoa (author)
Rennert, GadiCarmel Medical Center (author)
Chen, Chu (author)
Doherty, JenniferFred Hutchinson Cancer Research Center,University of Washington (author)
Goodman, GarySwedish Medical Center (author)
Bickeboeller, HeikeUniversity Medical Center Göttingen (author)
Wichmann, H-ErichHelmholtz Zentrum München,Technical University of Munich,World Orthopaedic Concern (author)
Risch, AngelaUniversity Hospital Heidelberg,University of Salzburg,German Center for Lung Research (DZL) (author)
Rosenberger, AlbertUniversity Medical Center Göttingen (author)
Shen, HongbingNanjing Medical University (author)
Dai, JunchengNanjing Medical University (author)
Field, John K.University of Liverpool (author)
Davies, MichaelUniversity of Liverpool (author)
Woll, PenellaUniversity of Sheffield (author)
Teare, M. DawnUniversity of Sheffield (author)
Kiemeney, Lambertus A.Radboud University Nijmegen,Dartmouth College (author)
van der Heijden, Erik H. F. M.Radboud University Nijmegen (author)
Yuan, Jian-MinUniversity of Pittsburgh Cancer Institute (author)
Hong, Yun-ChulSeoul National University Hospital (author)
Haugen, AageNational Institute of Occupational Health, Norway (author)
Zienolddiny, ShanbehNational Institute of Occupational Health, Norway (author)
Lam, StephenBritish Columbia Cancer Agency (author)
Tsao, Ming-SoundPrincess Margaret Hospital University of Toronto (author)
Johansson, MikaelUmeå University,Umeå universitet,Onkologi(Swepub:lu)ftf-mjo (author)
Grankvist, KjellUmeå University,Umeå universitet,Klinisk kemi(Swepub:umu)kjgr0002 (author)
Schabath, Matthew B.H. Lee Moffitt Cancer Center & Research Institute (author)
Andrew, Angeline (author)
Duell, EricCatalan Institute of Oncology (author)
Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital(Swepub:lu)endo-ome (author)
Brunnström, HansLund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-hsb (author)
Lazarus, PhilipWashington State University (author)
Arnold, SusanneUniversity of Kentucky Medical Center (author)
Slone, StaceyUniversity of Kentucky Medical Center (author)
Byun, JinyoungDartmouth College (author)
Kamal, AhsanDartmouth College (author)
Zhu, DakaiDartmouth College (author)
Landi, Maria TeresaNational Cancer Institute, USA (author)
Amos, Christopher, IDartmouth College (author)
Brennan, PaulInternational Agency for Research on Cancer, World Health Organization (author)
International Agency for Research on Cancer, World Health OrganizationUniversity of Toronto (creator_code:org_t)

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By the author/editor: Ferreiro-Iglesia ...; Lesseur, Corina; McKay, James; Hung, Rayjean J.; Han, Younghun; Zong, Xuchen; show more...; Christiani, Davi ...; Johansson, Matti ...; Xiao, Xiangjun; Li, Yafang; Qian, David C.; Ji, Xuemei; Liu, Geoffrey; Caporaso, Neil; Scelo, Ghislaine; Zaridze, David; Mukeriya, Anush; Kontic, Milica; Ognjanovic, Simo ...; Lissowska, Jolan ...; Szolkowska, Malg ...; Swiatkowska, Bea ...; Janout, Vladimir; Holcatova, Ivana; Bolca, Ciprian; Savic, Milan; Ognjanovic, Miod ...; Bojesen, Stig Eg ...; Wu, Xifeng; Albanes, Demetri ...; Aldrich, Melinda ...; Tardon, Adonina; Fernandez-Somoan ...; Fernandez-Tardon ...; Le Marchand, Loi ...; Rennert, Gadi; Chen, Chu; Doherty, Jennife ...; Goodman, Gary; Bickeboeller, He ...; Wichmann, H-Eric ...; Risch, Angela; Rosenberger, Alb ...; Shen, Hongbing; Dai, Juncheng; Field, John K.; Davies, Michael; Woll, Penella; Teare, M. Dawn; Kiemeney, Lamber ...; van der Heijden, ...; Yuan, Jian-Min; Hong, Yun-Chul; Haugen, Aage; Zienolddiny, Sha ...; Lam, Stephen; Tsao, Ming-Sound; Johansson, Mikae ...; Grankvist, Kjell; Schabath, Matthe ...; Andrew, Angeline; Duell, Eric; Melander, Olle; Brunnström, Hans; Lazarus, Philip; Arnold, Susanne; Slone, Stacey; Byun, Jinyoung; Kamal, Ahsan; Zhu, Dakai; Landi, Maria Ter ...; Amos, Christophe ...; Brennan, Paul; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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