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Linkage but not association of calpain-10 to type 2 diabetes replicated in northern Sweden
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- Einarsdottir, Elisabet (author)
- Umeå universitet,Medicinsk och klinisk genetik
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- Mayans, Sofia (author)
- Umeå universitet,Medicinsk och klinisk genetik
- Ruikka, Karin (author)
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- (creator_code:org_t)
- American Diabetes Association, 2006
- 2006
- English.
- In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 55:6, s. 1879-1883
- Journal article (peer-reviewed)
Abstract
Subject headings
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- We present data from a genome-wide scan identifying genetic factors conferring susceptibility to type 2 diabetes. The linkage analysis was based on 59 families from northern Sweden, consisting of a total of 129 cases of type 2 diabetes and 19 individuals with impaired glucose tolerance. Model-free linkage analysis revealed a maximum multipoint logarithm of odds score of 3.19 for D2S2987 at 267.7 cM (P = 0.00058), suggesting that a gene conferring susceptibility to type 2 diabetes in the northern Swedish population resides in the 2q37 region. These data replicate, in a European population, previously identified linkage of marker loci in this region to type 2 diabetes in Mexican Americans. In contrast, no evidence in support of association to the previously identified single nucleotide polymorphisms in the calpain-10 gene was observed in a case-control cohort derived from the same population.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- Eliasson, Mats
- Holmberg, Dan
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- Diabetes
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