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Long-Term Effects o...
Long-Term Effects of Oxygen Therapy on Death or Hospitalization for Heart Failure in Patients With Suspected Acute Myocardial Infarction
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- Jernberg, Tomas (author)
- Karolinska Institutet
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- Lindahl, Bertil, 1957- (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala Univ, Sweden
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- Alfredsson, Joakim (author)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Berglund, Ellinor (author)
- Karolinska Institutet
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- Bergström, Olle (author)
- Vaxjo Hosp, Dept Med, Vaxjo, Sweden
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- Engström, Anders (author)
- Kalmar Reg Hosp, Div Cardiol, Dept Med, Kalmar, Sweden
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- Erlinge, David (author)
- Lund Univ, Dept Clin Sci, Cardiol, Lund, Sweden
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- Herlitz, Johan (author)
- Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden;Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Cardiol, Gothenburg, Sweden;Univ Boras, Dept Hlth Sci, Boras, Sweden
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- Jumatate, Raluca (author)
- Kristianstad Hosp, Dept Med, Kristianstad, Sweden
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- Kellerth, Thomas (author)
- Orebro Univ Hosp, Dept Cardiol, Orebro, Sweden
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- Lauermann, Jörg (author)
- Ryhov Hosp, Div Cardiol, Dept Internal Med, Jonkoping, Sweden
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- Lindmark, Krister (author)
- Umeå universitet,Kardiologi,Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden
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- Lingman, Markus (author)
- Halland Hosp, Dept Med, Halmstad, Sweden;Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden
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- Ljung, Lina (author)
- Karolinska Institutet
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- Nilsson, Carina (author)
- Ljungby Hosp, Dept Med, Ljungby, Sweden
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- Omerovic, Elmir (author)
- Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden;Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Cardiol, Gothenburg, Sweden
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- Pernow, John (author)
- Karolinska Institutet
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- Ravn-Fischer, Annica (author)
- Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden;Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Cardiol, Gothenburg, Sweden
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- Sparv, David (author)
- Lund Univ, Dept Clin Sci, Cardiol, Lund, Sweden
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- Yndigegn, Troels (author)
- Lund Univ, Dept Clin Sci, Cardiol, Lund, Sweden
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- Östlund, Ollie (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Uppsala Univ, Sweden
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- James, Stefan K, 1964- (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala Univ, Sweden
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- Hofmann, Robin (author)
- Karolinska Institutet
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(creator_code:org_t)
- LIPPINCOTT WILLIAMS & WILKINS, 2018
- 2018
- English.
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In: Circulation. - : LIPPINCOTT WILLIAMS & WILKINS. - 0009-7322 .- 1524-4539. ; 138:24, s. 2754-2762
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
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- Background: In the DETO2X-AMI trial (Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction), we compared supplemental oxygen with ambient air in normoxemic patients presenting with suspected myocardial infarction and found no significant survival benefit at 1 year. However, important secondary end points were not yet available. We now report the prespecified secondary end points cardiovascular death and the composite of all-cause death and hospitalization for heart failure.Methods: In this pragmatic, registry-based randomized clinical trial, we used a nationwide quality registry for coronary care for trial procedures and evaluated end points through the Swedish population registry (mortality), the Swedish inpatient registry (heart failure), and cause of death registry (cardiovascular death). Patients with suspected acute myocardial infarction and oxygen saturation of ≥90% were randomly assigned to receive either supplemental oxygen at 6 L/min for 6 to 12 hours delivered by open face mask or ambient air.Results: A total of 6629 patients were enrolled. Acute heart failure treatment, left ventricular systolic function assessed by echocardiography, and infarct size measured by high-sensitive cardiac troponin T were similar in the 2 groups during the hospitalization period. All-cause death or hospitalization for heart failure within 1 year after randomization occurred in 8.0% of patients assigned to oxygen and in 7.9% of patients assigned to ambient air (hazard ratio, 0.99; 95% CI, 0.84–1.18; P=0.92). During long-term follow-up (median [range], 2.1 [1.0–3.7] years), the composite end point occurred in 11.2% of patients assigned to oxygen and in 10.8% of patients assigned to ambient air (hazard ratio, 1.02; 95% CI, 0.88–1.17; P=0.84), and cardiovascular death occurred in 5.2% of patients assigned to oxygen and in 4.8% assigned to ambient air (hazard ratio, 1.07; 95% CI, 0.87–1.33; P=0.52). The results were consistent across all predefined subgroups.Conclusions: Routine use of supplemental oxygen in normoxemic patients with suspected myocardial infarction was not found to reduce the composite of all-cause mortality and hospitalization for heart failure, or cardiovascular death within 1 year or during long-term follow-up.Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01787110.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- death
- heart failure
- hospitalization
- mortality
- myocardial infarction
- oxygen inhalation therapy
- registries
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Jernberg, Tomas
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Lindahl, Bertil, ...
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Alfredsson, Joak ...
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Berglund, Ellino ...
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Bergström, Olle
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Engström, Anders
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show more...
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Erlinge, David
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Herlitz, Johan
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Jumatate, Raluca
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Kellerth, Thomas
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Lauermann, Jörg
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Lindmark, Kriste ...
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Lingman, Markus
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Ljung, Lina
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Nilsson, Carina
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Omerovic, Elmir
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Pernow, John
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Ravn-Fischer, An ...
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Sparv, David
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Yndigegn, Troels
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Östlund, Ollie
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James, Stefan K, ...
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Hofmann, Robin
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Circulation
- By the university
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Umeå University
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Uppsala University
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Linköping University
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Karolinska Institutet