A comprehensive evaluation of the genetic architecture of sudden cardiac arrest

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MARC

Ashar, Foram N.Johns Hopkins University (author)

A comprehensive evaluation of the genetic architecture of sudden cardiac arrest

Article/chapterEnglish2018

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2018-08-28
Oxford University Press,2018
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LIBRIS-ID:oai:DiVA.org:umu-155117
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-155117URI
https://doi.org/10.1093/eurheartj/ehy474DOI
https://lup.lub.lu.se/record/2f647862-915a-43a0-942f-14653d6811abURI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Aims: Sudden cardiac arrest (SCA) accounts for 10% of adult mortality in Western populations. We aim to identify potential loci associated with SCA and to identify risk factors causally associated with SCA.Methods and results: We carried out a large genome-wide association study (GWAS) for SCA (n = 3939 cases, 25 989 non-cases) to examine common variation genome-wide and in candidate arrhythmia genes. We also exploited Mendelian randomization (MR) methods using cross-trait multi-variant genetic risk score associations (GRSA) to assess causal relationships of 18 risk factors with SCA. No variants were associated with SCA at genome-wide significance, nor were common variants in candidate arrhythmia genes associated with SCA at nominal significance. Using cross-trait GRSA, we established genetic correlation between SCA and (i) coronary artery disease (CAD) and traditional CAD risk factors (blood pressure, lipids, and diabetes), (ii) height and BMI, and (iii) electrical instability traits (QT and atrial fibrillation), suggesting aetiologic roles for these traits in SCA risk.Conclusions: Our findings show that a comprehensive approach to the genetic architecture of SCA can shed light on the determinants of a complex life-threatening condition with multiple influencing factors in the general population. The results of this genetic analysis, both positive and negative findings, have implications for evaluating the genetic architecture of patients with a family history of SCA, and for efforts to prevent SCA in high-risk populations and the general community.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Sudden cardiac arrest
Genome-wide association study
Mendelian randomization

Added entries (persons, corporate bodies, meetings, titles ...)

Mitchell, Rebecca N. (author)
Albert, Christine M. (author)
Newton-Cheh, Christopher (author)
Brody, Jennifer A. (author)
Mueller-Nurasyid, Martina (author)
Moes, Anna (author)
Meitinger, Thomas (author)
Mak, Angel (author)
Huikuri, Heikki (author)
Junttila, M. Juhani (author)
Goyette, Philippe (author)
Pulit, Sara L. (author)
Pazoki, Raha (author)
Tanck, MichaelW. (author)
Blom, Marieke T. (author)
Zhao, XiaoQing (author)
Havulinna, Aki S. (author)
Jabbari, Reza (author)
Glinge, Charlotte (author)
Tragante, Vinicius (author)
Escher, Stefan A. (author)
Chakravarti, Aravinda (author)
Ehret, Georg (author)
Coresh, Josef (author)
Li, Man (author)
Prineas, Ronald J. (author)
Franco, Oscar H. (author)
Kwok, Pui-Yan (author)
Lumley, Thomas (author)
Dumas, Florence (author)
McKnight, Barbara (author)
Rotter, Jerome I. (author)
Lemaitre, Rozenn N. (author)
Heckbert, Susan R. (author)
O'Donnell, Christopher J. (author)
Hwang, Shih-Jen (author)
Tardif, Jean-Claude (author)
VanDenburgh, Martin (author)
Uitterlinden, Andre G. (author)
Hofman, Albert (author)
Stricker, Bruno H. C. (author)
de Bakker, Paul I. W. (author)
Franks, Paul W.Lund University,Lunds universitet,Umeå universitet,Avdelningen för medicin,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-plf (author)
Jansson, Jan-HåkanUmeå universitet,Medicin,Research Unit Skelleftea(Swepub:umu)jaja0006 (author)
Asselbergs, Folkert W. (author)
Halushka, Marc K. (author)
Maleszewski, Joseph J. (author)
Tfelt-Hansen, Jacob (author)
Engström, ThomasLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Copenhagen University Hospital(Swepub:lu)th4331en (author)
Salomaa, Veikko (author)
Virmani, Renu (author)
Kolodgie, Frank (author)
Wilde, Arthur A. M. (author)
Tan, Hanno L. (author)
Bezzina, Connie R. (author)
Eijgelsheim, Mark (author)
Rioux, John D. (author)
Jouven, Xavier (author)
Kääb, Stefan (author)
Psaty, Bruce M. (author)
Siscovick, David S. (author)
Arking, Dan E.Johns Hopkins University (author)
Sotoodehnia, NonaUniversity of Washington (author)
Johns Hopkins UniversityAvdelningen för medicin (creator_code:org_t)
et al.

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In:European Heart Journal: Oxford University Press39:44, s. 3961-+0195-668X1522-9645

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By the author/editor: Ashar, Foram N.; Mitchell, Rebecc ...; Albert, Christin ...; Newton-Cheh, Chr ...; Brody, Jennifer ...; Mueller-Nurasyid ...; show more...; Moes, Anna; Meitinger, Thoma ...; Mak, Angel; Huikuri, Heikki; Junttila, M. Juh ...; Goyette, Philipp ...; Pulit, Sara L.; Pazoki, Raha; Tanck, MichaelW.; Blom, Marieke T.; Zhao, XiaoQing; Havulinna, Aki S ...; Jabbari, Reza; Glinge, Charlott ...; Tragante, Vinici ...; Escher, Stefan A ...; Chakravarti, Ara ...; Ehret, Georg; Coresh, Josef; Li, Man; Prineas, Ronald ...; Franco, Oscar H.; Kwok, Pui-Yan; Lumley, Thomas; Dumas, Florence; McKnight, Barbar ...; Rotter, Jerome I ...; Lemaitre, Rozenn ...; Heckbert, Susan ...; O'Donnell, Chris ...; Hwang, Shih-Jen; Tardif, Jean-Cla ...; VanDenburgh, Mar ...; Uitterlinden, An ...; Hofman, Albert; Stricker, Bruno ...; de Bakker, Paul ...; Franks, Paul W.; Jansson, Jan-Håk ...; Asselbergs, Folk ...; Halushka, Marc K ...; Maleszewski, Jos ...; Tfelt-Hansen, Ja ...; Engström, Thomas; Salomaa, Veikko; Virmani, Renu; Kolodgie, Frank; Wilde, Arthur A. ...; Tan, Hanno L.; Bezzina, Connie ...; Eijgelsheim, Mar ...; Rioux, John D.; Jouven, Xavier; Kääb, Stefan; Psaty, Bruce M.; Siscovick, David ...; Arking, Dan E.; Sotoodehnia, Non ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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