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A comprehensive eva...
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Ashar, Foram N.Johns Hopkins University
(author)
A comprehensive evaluation of the genetic architecture of sudden cardiac arrest
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-08-28
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Oxford University Press,2018
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-155117
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-155117URI
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https://doi.org/10.1093/eurheartj/ehy474DOI
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https://lup.lub.lu.se/record/2f647862-915a-43a0-942f-14653d6811abURI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Aims: Sudden cardiac arrest (SCA) accounts for 10% of adult mortality in Western populations. We aim to identify potential loci associated with SCA and to identify risk factors causally associated with SCA.Methods and results: We carried out a large genome-wide association study (GWAS) for SCA (n = 3939 cases, 25 989 non-cases) to examine common variation genome-wide and in candidate arrhythmia genes. We also exploited Mendelian randomization (MR) methods using cross-trait multi-variant genetic risk score associations (GRSA) to assess causal relationships of 18 risk factors with SCA. No variants were associated with SCA at genome-wide significance, nor were common variants in candidate arrhythmia genes associated with SCA at nominal significance. Using cross-trait GRSA, we established genetic correlation between SCA and (i) coronary artery disease (CAD) and traditional CAD risk factors (blood pressure, lipids, and diabetes), (ii) height and BMI, and (iii) electrical instability traits (QT and atrial fibrillation), suggesting aetiologic roles for these traits in SCA risk.Conclusions: Our findings show that a comprehensive approach to the genetic architecture of SCA can shed light on the determinants of a complex life-threatening condition with multiple influencing factors in the general population. The results of this genetic analysis, both positive and negative findings, have implications for evaluating the genetic architecture of patients with a family history of SCA, and for efforts to prevent SCA in high-risk populations and the general community.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Mitchell, Rebecca N.
(author)
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Albert, Christine M.
(author)
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Newton-Cheh, Christopher
(author)
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Brody, Jennifer A.
(author)
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Mueller-Nurasyid, Martina
(author)
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Moes, Anna
(author)
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Meitinger, Thomas
(author)
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Mak, Angel
(author)
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Huikuri, Heikki
(author)
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Junttila, M. Juhani
(author)
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Goyette, Philippe
(author)
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Pulit, Sara L.
(author)
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Pazoki, Raha
(author)
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Tanck, MichaelW.
(author)
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Blom, Marieke T.
(author)
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Zhao, XiaoQing
(author)
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Havulinna, Aki S.
(author)
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Jabbari, Reza
(author)
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Glinge, Charlotte
(author)
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Tragante, Vinicius
(author)
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Escher, Stefan A.
(author)
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Chakravarti, Aravinda
(author)
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Ehret, Georg
(author)
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Coresh, Josef
(author)
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Li, Man
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Prineas, Ronald J.
(author)
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Franco, Oscar H.
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Kwok, Pui-Yan
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Lumley, Thomas
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Dumas, Florence
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McKnight, Barbara
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Rotter, Jerome I.
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Lemaitre, Rozenn N.
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Heckbert, Susan R.
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O'Donnell, Christopher J.
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Hwang, Shih-Jen
(author)
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Tardif, Jean-Claude
(author)
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VanDenburgh, Martin
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Uitterlinden, Andre G.
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Hofman, Albert
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Stricker, Bruno H. C.
(author)
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de Bakker, Paul I. W.
(author)
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Franks, Paul W.Lund University,Lunds universitet,Umeå universitet,Avdelningen för medicin,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-plf
(author)
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Jansson, Jan-HåkanUmeå universitet,Medicin,Research Unit Skelleftea(Swepub:umu)jaja0006
(author)
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Asselbergs, Folkert W.
(author)
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Halushka, Marc K.
(author)
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Maleszewski, Joseph J.
(author)
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Tfelt-Hansen, Jacob
(author)
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Engström, ThomasLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Copenhagen University Hospital(Swepub:lu)th4331en
(author)
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Salomaa, Veikko
(author)
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Virmani, Renu
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Kolodgie, Frank
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Wilde, Arthur A. M.
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Tan, Hanno L.
(author)
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Bezzina, Connie R.
(author)
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Eijgelsheim, Mark
(author)
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Rioux, John D.
(author)
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Jouven, Xavier
(author)
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Kääb, Stefan
(author)
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Psaty, Bruce M.
(author)
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Siscovick, David S.
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Arking, Dan E.Johns Hopkins University
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Sotoodehnia, NonaUniversity of Washington
(author)
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Johns Hopkins UniversityAvdelningen för medicin
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et al.
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In:European Heart Journal: Oxford University Press39:44, s. 3961-+0195-668X1522-9645
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Ashar, Foram N.
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Mitchell, Rebecc ...
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Albert, Christin ...
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Newton-Cheh, Chr ...
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Brody, Jennifer ...
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Mueller-Nurasyid ...
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Moes, Anna
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Meitinger, Thoma ...
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Mak, Angel
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Huikuri, Heikki
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Junttila, M. Juh ...
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Goyette, Philipp ...
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Pulit, Sara L.
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Pazoki, Raha
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Tanck, MichaelW.
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Blom, Marieke T.
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Zhao, XiaoQing
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Havulinna, Aki S ...
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Jabbari, Reza
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Glinge, Charlott ...
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Tragante, Vinici ...
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Escher, Stefan A ...
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Chakravarti, Ara ...
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Ehret, Georg
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Coresh, Josef
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Li, Man
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Prineas, Ronald ...
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Franco, Oscar H.
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Kwok, Pui-Yan
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Lumley, Thomas
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Dumas, Florence
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McKnight, Barbar ...
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Rotter, Jerome I ...
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Lemaitre, Rozenn ...
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Heckbert, Susan ...
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O'Donnell, Chris ...
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Hwang, Shih-Jen
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Tardif, Jean-Cla ...
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VanDenburgh, Mar ...
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Uitterlinden, An ...
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Hofman, Albert
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Stricker, Bruno ...
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de Bakker, Paul ...
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Franks, Paul W.
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Jansson, Jan-Håk ...
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Asselbergs, Folk ...
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Halushka, Marc K ...
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Maleszewski, Jos ...
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Tfelt-Hansen, Ja ...
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Engström, Thomas
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Salomaa, Veikko
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Virmani, Renu
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Kolodgie, Frank
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Wilde, Arthur A. ...
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Tan, Hanno L.
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Bezzina, Connie ...
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Eijgelsheim, Mar ...
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Rioux, John D.
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Jouven, Xavier
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Kääb, Stefan
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Psaty, Bruce M.
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Arking, Dan E.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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European Heart J ...
- By the university
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Umeå University
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Lund University