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Flagella-mediated s...
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Dongre, MiteshUmeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Molekylär Infektionsmedicin, Sverige (MIMS)
(author)
Flagella-mediated secretion of a novel Vibrio cholerae cytotoxin affecting both vertebrate and invertebrate hosts
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-06-07
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Springer Nature Publishing AG,2018
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-155563
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-155563URI
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https://doi.org/10.1038/s42003-018-0065-zDOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Using Caenorhabditis elegans as an infection host model for Vibrio cholerae predator interactions, we discovered a bacterial cytotoxin, MakA, whose function as a virulence factor relies on secretion via the flagellum channel in a proton motive force-dependent manner. The MakA protein is expressed from the polycistronic makDCBA (motility-associated killing factor) operon. Bacteria expressing makDCBA induced dramatic changes in intestinal morphology leading to a defecation defect, starvation and death in C. elegans. The Mak proteins also promoted V. cholerae colonization of the zebrafish gut causing lethal infection. A structural model of purified MakA at 1.9 Å resolution indicated similarities to members of a superfamily of bacterial toxins with unknown biological roles. Our findings reveal an unrecognized role for V. cholerae flagella in cytotoxin export that may contribute both to environmental spread of the bacteria by promoting survival and proliferation in encounters with predators, and to pathophysiological effects during infections.
Subject headings and genre
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Singh, BhupenderUmeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Molekylär Infektionsmedicin, Sverige (MIMS)
(author)
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Aung, Kyaw MinUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten)(Swepub:umu)kymi0003
(author)
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Larsson, PerUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten)(Swepub:umu)pela0108
(author)
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Miftakhova, Regina R.Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Molekylär Infektionsmedicin, Sverige (MIMS)(Swepub:umu)remi0008
(author)
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Persson, KarinaUmeå universitet,Kemiska institutionen(Swepub:umu)kape0001
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Askarian, Fatemeh
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Johannessen, Mona
(author)
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von Hofsten, JonasUmeå universitet,Umeå centrum för molekylär medicin (UCMM),Institutionen för integrativ medicinsk biologi (IMB)(Swepub:umu)josvon97
(author)
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Persson, Jenny L.Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Molekylär Infektionsmedicin, Sverige (MIMS)(Swepub:umu)jepe0128
(author)
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Erhardt, Marc
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Tuck, SimonUmeå universitet,Umeå centrum för molekylär medicin (UCMM)(Swepub:umu)situ0001
(author)
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Uhlin, Bernt EricUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten)(Swepub:umu)beuh0001
(author)
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Wai, Sun NyuntUmeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Molekylär Infektionsmedicin, Sverige (MIMS)(Swepub:umu)suwa0005
(author)
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Umeå universitetInstitutionen för molekylärbiologi (Medicinska fakulteten)
(creator_code:org_t)
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In:Communications Biology: Springer Nature Publishing AG12399-3642
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Dongre, Mitesh
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Singh, Bhupender
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Aung, Kyaw Min
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Larsson, Per
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Miftakhova, Regi ...
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Persson, Karina
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Askarian, Fateme ...
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Johannessen, Mon ...
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von Hofsten, Jon ...
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Persson, Jenny L ...
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Erhardt, Marc
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Tuck, Simon
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Uhlin, Bernt Eri ...
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Wai, Sun Nyunt
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