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Dorsal striatal dop...
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de Boer, LiekeKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
(author)
Dorsal striatal dopamine D1 receptor availability predicts an instrumental bias in action learning
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2018-12-18
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National Academy of Sciences,2019
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Numbers
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LIBRIS-ID:oai:DiVA.org:umu-155637
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-155637URI
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https://doi.org/10.1073/pnas.1816704116DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-165695URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:139959484URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Learning to act to obtain reward and inhibit to avoid punishment is easier compared with learning the opposite contingencies. This coupling of action and valence is often thought of as a Pavlovian bias, although recent research has shown it may also emerge through instrumental mechanisms. We measured this learning bias with a rewarded go/no-go task in 60 adults of different ages. Using computational modeling, we characterized the bias as being instrumental. To assess the role of endogenous dopamine (DA) in the expression of this bias, we quantified DA D1 receptor availability using positron emission tomography (PET) with the radioligand [11C]SCH23390. Using principal-component analysis on the binding potentials in a number of cortical and striatal regions of interest, we demonstrated that cortical, dorsal striatal, and ventral striatal areas provide independent sources of variance in DA D1 receptor availability. Interindividual variation in the dorsal striatal component was related to the strength of the instrumental bias during learning. These data suggest at least three anatomical sources of variance in DA D1 receptor availability separable using PET in humans, and we provide evidence that human dorsal striatal DA D1 receptors are involved in the modulation of instrumental learning biases.
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Axelsson, Jan,1966-Umeå universitet,Radiofysik,Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)jaax0004
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Chowdhury, Rumana
(author)
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Riklund, KatrineUmeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)kaah0001
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Dolan, Raymond J.
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Nyberg, Lars,1966-Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi,Fysiologi(Swepub:umu)lany0001
(author)
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Backman, LarsKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
(author)
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Guitart-Masip, MarcKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),University College London, UK
(author)
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Stockholms universitetCentrum för forskning om äldre och åldrande (ARC), (tills m KI)
(creator_code:org_t)
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In:Proceedings of the National Academy of Sciences of the United States of America: National Academy of Sciences116:1, s. 261-2700027-84241091-6490
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de Boer, Lieke
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Axelsson, Jan, 1 ...
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Riklund, Katrine
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Dolan, Raymond J ...
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Nyberg, Lars, 19 ...
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Backman, Lars
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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Umeå University
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Stockholm University
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Karolinska Institutet