Perfluoroalkyl substances and risk of type II diabetes: A prospective nested case-control study

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Perfluoroalkyl substances and risk of type II diabetes : A prospective nested case-control study

Donat-Vargas, Carolina (author): Karolinska Institutet

Bergdahl, Ingvar (author): Umeå universitet,Yrkes- och miljömedicin

Tornevi, Andreas (author): Umeå universitet,Yrkes- och miljömedicin

Wennberg, Maria, 1974- (author): Umeå universitet,Näringsforskning

Sommar, Johan (author): Umeå universitet,Yrkes- och miljömedicin

Kiviranta, Hannu (author)

Koponen, Jani (author)

Rolandsson, Olov (author): Umeå universitet,Allmänmedicin

Akesson, Agneta (author): Karolinska Institutet

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(creator_code:org_t)

Elsevier, 2019
2019
English.
In: Environment International. - : Elsevier. - 0160-4120 .- 1873-6750. ; 123, s. 390-398

Related links:: https://doi.org/10.1...; show more...; https://umu.diva-por... (primary) (Raw object); https://doi.org/10.1...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: Perfluoroalkyl substances (PFAS) have drawn much attention due to bioaccumulation potential and their current omnipresence in human blood. We assessed whether plasma PFAS, suspected to induce endocrine-disrupting effects, were prospectively associated with clinical type 2 diabetes (T2D) risk.Methods: We established a nested case-control study within the Swedish prospective population-based Västerbotten Intervention Programme cohort. Several PFAS were measured in plasma from a subset of 124 case-control pairs at baseline (during 1990–2003) and at 10-year follow-up. T2D cases were matched (1:1) according to gender, age and sample date with participants without T2D (controls).Conditional logistic regressions were used to prospectively assess risk of T2D by baseline PFAS plasma concentrations. Associations between long-term PFAS plasma levels (mean of baseline and follow-up) and insulin resistance (HOMA2-IR) and beta-cell function (HOMA2-B%) at follow-up were prospectively explored among 178 and 181 controls, respectively, by multivariable linear regressions.Results: After adjusting for gender, age, sample year, diet and body mass index, the odds ratio of T2D for the sum of PFAS (Σ z-score PFAS) was 0.52 (95% confidence interval, CI: 0.20, 1.36), comparing third with first tertile; and 0.92 (95% CI: 0.84, 1.00) per one standard deviation increment of sum of log-transformed PFAS. Among the controls, the adjusted β of HOMA2-IR and HOMA-B% for the sum of PFAS were −0.26 (95% CI: −0.52, −0.01) and −9.61 (95% CI: −22.60, 3.39) respectively comparing third with first tertile.Conclusions: This prospective nested case-control study yielded overall inverse associations between individual PFAS and risk of T2D, although mostly non-significant. Among participants without T2D, long-term PFAS exposure was prospectively associated with lower insulin resistance.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Keyword

Environmental contaminants
Plasma perfluoroalkyl substances
Environmental risk factors
Diabetes
Insulin resistance
Endocrine disruption
Environmental epidemiology
Nested case-control study
Prospective assessment

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor: Donat-Vargas, Ca ...; Bergdahl, Ingvar; Tornevi, Andreas; Wennberg, Maria, ...; Sommar, Johan; Kiviranta, Hannu; show more...; Koponen, Jani; Rolandsson, Olov; Akesson, Agneta; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

Articles in the publication: Environment Inte ...

By the university: Umeå University; Karolinska Institutet

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