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Perfluoroalkyl subs...
Perfluoroalkyl substances and risk of type II diabetes : A prospective nested case-control study
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- Donat-Vargas, Carolina (author)
- Karolinska Institutet
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- Bergdahl, Ingvar (author)
- Umeå universitet,Yrkes- och miljömedicin
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- Tornevi, Andreas (author)
- Umeå universitet,Yrkes- och miljömedicin
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- Wennberg, Maria, 1974- (author)
- Umeå universitet,Näringsforskning
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- Sommar, Johan (author)
- Umeå universitet,Yrkes- och miljömedicin
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Kiviranta, Hannu (author)
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Koponen, Jani (author)
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- Rolandsson, Olov (author)
- Umeå universitet,Allmänmedicin
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- Akesson, Agneta (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier, 2019
- 2019
- English.
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In: Environment International. - : Elsevier. - 0160-4120 .- 1873-6750. ; 123, s. 390-398
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https://doi.org/10.1...
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Abstract
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- Background: Perfluoroalkyl substances (PFAS) have drawn much attention due to bioaccumulation potential and their current omnipresence in human blood. We assessed whether plasma PFAS, suspected to induce endocrine-disrupting effects, were prospectively associated with clinical type 2 diabetes (T2D) risk.Methods: We established a nested case-control study within the Swedish prospective population-based Västerbotten Intervention Programme cohort. Several PFAS were measured in plasma from a subset of 124 case-control pairs at baseline (during 1990–2003) and at 10-year follow-up. T2D cases were matched (1:1) according to gender, age and sample date with participants without T2D (controls).Conditional logistic regressions were used to prospectively assess risk of T2D by baseline PFAS plasma concentrations. Associations between long-term PFAS plasma levels (mean of baseline and follow-up) and insulin resistance (HOMA2-IR) and beta-cell function (HOMA2-B%) at follow-up were prospectively explored among 178 and 181 controls, respectively, by multivariable linear regressions.Results: After adjusting for gender, age, sample year, diet and body mass index, the odds ratio of T2D for the sum of PFAS (Σ z-score PFAS) was 0.52 (95% confidence interval, CI: 0.20, 1.36), comparing third with first tertile; and 0.92 (95% CI: 0.84, 1.00) per one standard deviation increment of sum of log-transformed PFAS. Among the controls, the adjusted β of HOMA2-IR and HOMA-B% for the sum of PFAS were −0.26 (95% CI: −0.52, −0.01) and −9.61 (95% CI: −22.60, 3.39) respectively comparing third with first tertile.Conclusions: This prospective nested case-control study yielded overall inverse associations between individual PFAS and risk of T2D, although mostly non-significant. Among participants without T2D, long-term PFAS exposure was prospectively associated with lower insulin resistance.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Environmental contaminants
- Plasma perfluoroalkyl substances
- Environmental risk factors
- Diabetes
- Insulin resistance
- Endocrine disruption
- Environmental epidemiology
- Nested case-control study
- Prospective assessment
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Donat-Vargas, Ca ...
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Bergdahl, Ingvar
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Tornevi, Andreas
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Wennberg, Maria, ...
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Sommar, Johan
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Kiviranta, Hannu
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show more...
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Koponen, Jani
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Rolandsson, Olov
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Akesson, Agneta
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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Environment Inte ...
- By the university
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Umeå University
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Karolinska Institutet