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Topological data an...
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Schofield, James P. R.
(author)
Topological data analysis (TDA) of U-BIOPRED paediatric peripheral blood gene expression identified asthma phenotypes characterised by alternative splicing of glucocorticoid receptor (GR) mRNA
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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European Respiratory Society,2018
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Numbers
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LIBRIS-ID:oai:DiVA.org:umu-155991
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-155991URI
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https://doi.org/10.1183/13993003.congress-2018.PA5435DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:140044375URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:vet swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Supplement: 62Meeting Abstract: PA5435
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Background: Molecular stratification of childhood asthma could enable targeted therapy.Aims: Unbiased analysis of gene expression in paediatric severe (SA) and moderate/mild asthma (MA) blood samples to identify sub-phenotypes.Methods: Transcriptomic profiling by microarray analysis of blood from the U-BIOPRED paediatric cohort (Fleming ERJ 2015), pre- and school-age children, (SApre, n=62; MApre, n=42; SAsc, n=75 and MAsc, n=37). Topological data analysis (TDA) was used for unbiased clustering.Results: Sub-phenotypes, P1, P2, P3 and P4 were identified and are highlighted in the TDA network in the figure and a heatmap of selected variables. P1 (38% of the cohort, median 11 yrs) was characterised by low expression of glucocorticoid receptor (GR) mRNA splice variant with a long 3’ UTR (q = 2.43E-17), but no significant difference in the expression of glucocorticoid receptor (GR) mRNA splice variant with a short 3’ UTR. In P1, COX2 expression was up (q = 1.89E-06) and IFN-γ was down (q = 5.61E-06), characteristics of a decreased steroid response.Conclusion: Unbiased analysis of U-BIOPRED paediatric peripheral blood gene expression identified a sub-phenotype, P1, with an inhibited steroid response. P1 is associated with low expression of a splice variant of GR with a long 3’ UTR.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Bigler, Jeanette
(author)
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Boedigheimer, Michael
(author)
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Affleck, Karen
(author)
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Taylor, Adam
(author)
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Pavlidis, Stelios
(author)
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Riley, John H.
(author)
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Strazzeri, Fabio
(author)
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Roberts, Graham
(author)
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Brandsma, Joost
(author)
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Bansal, Aruna
(author)
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Nicholas, Ben
(author)
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Xian, Yang
(author)
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Rowe, Anthony
(author)
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Corfield, Julie
(author)
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Wilson, Susan
(author)
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Ward, Jonathan
(author)
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Lutter, Rene
(author)
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Fleming, Louise
(author)
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Shaw, Dominick
(author)
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Per, Bakke
(author)
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Caruso, Massimo
(author)
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Dahlen, Sven-Erik
(author)
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Fowler, Stephen
(author)
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Hashimoto, Simone
(author)
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Horvath, Ildiko
(author)
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Howarth, Peter
(author)
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Krug, Norbert
(author)
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Montuschi, Paolo
(author)
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Sanak, Marek
(author)
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Sandström, Thomas,1957-Umeå universitet(Swepub:umu)thsa0001
(author)
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Singer, Florian
(author)
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Sun, Kai
(author)
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Pandis, Ioannis
(author)
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Auffray, Charles
(author)
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de Meulder, Bertrand
(author)
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Lefaudeux, Diane
(author)
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Knowles, Richard
(author)
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Fitch, Neil
(author)
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Sousa, Ana
(author)
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Adcock, Ian
(author)
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Chung, Kian Fan
(author)
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Sterk, Peter
(author)
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Skipp, Paul
(author)
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Djukanovic, Ratko
(author)
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Umeå universitet
(creator_code:org_t)
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In:European Respiratory Journal: European Respiratory Society520903-19361399-3003
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Schofield, James ...
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Bigler, Jeanette
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Boedigheimer, Mi ...
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Affleck, Karen
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Taylor, Adam
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Pavlidis, Stelio ...
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Riley, John H.
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Strazzeri, Fabio
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Roberts, Graham
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Brandsma, Joost
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Bansal, Aruna
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Nicholas, Ben
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Xian, Yang
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Rowe, Anthony
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Corfield, Julie
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Wilson, Susan
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Ward, Jonathan
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Lutter, Rene
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Fleming, Louise
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Shaw, Dominick
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Per, Bakke
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Caruso, Massimo
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Dahlen, Sven-Eri ...
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Fowler, Stephen
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Hashimoto, Simon ...
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Horvath, Ildiko
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Howarth, Peter
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Krug, Norbert
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Montuschi, Paolo
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Sanak, Marek
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Sandström, Thoma ...
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Singer, Florian
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Sun, Kai
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Pandis, Ioannis
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Auffray, Charles
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de Meulder, Bert ...
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Lefaudeux, Diane
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Knowles, Richard
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Fitch, Neil
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Sousa, Ana
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Adcock, Ian
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Chung, Kian Fan
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Sterk, Peter
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Skipp, Paul
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Djukanovic, Ratk ...
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Umeå University
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Karolinska Institutet