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Topological data an...
Topological data analysis (TDA) of U-BIOPRED paediatric peripheral blood gene expression identified asthma phenotypes characterised by alternative splicing of glucocorticoid receptor (GR) mRNA
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Schofield, James P. R. (author)
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Bigler, Jeanette (author)
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Boedigheimer, Michael (author)
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Affleck, Karen (author)
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Taylor, Adam (author)
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Pavlidis, Stelios (author)
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Riley, John H. (author)
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Strazzeri, Fabio (author)
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Roberts, Graham (author)
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Brandsma, Joost (author)
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Bansal, Aruna (author)
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Nicholas, Ben (author)
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Xian, Yang (author)
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Rowe, Anthony (author)
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Corfield, Julie (author)
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Wilson, Susan (author)
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Ward, Jonathan (author)
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Lutter, Rene (author)
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Fleming, Louise (author)
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Shaw, Dominick (author)
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Per, Bakke (author)
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Caruso, Massimo (author)
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Dahlen, Sven-Erik (author)
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Fowler, Stephen (author)
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Hashimoto, Simone (author)
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Horvath, Ildiko (author)
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Howarth, Peter (author)
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Krug, Norbert (author)
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Montuschi, Paolo (author)
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Sanak, Marek (author)
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- Sandström, Thomas, 1957- (author)
- Umeå universitet
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Singer, Florian (author)
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Sun, Kai (author)
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Pandis, Ioannis (author)
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Auffray, Charles (author)
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de Meulder, Bertrand (author)
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Lefaudeux, Diane (author)
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Knowles, Richard (author)
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Fitch, Neil (author)
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Sousa, Ana (author)
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Adcock, Ian (author)
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Chung, Kian Fan (author)
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Sterk, Peter (author)
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Skipp, Paul (author)
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Djukanovic, Ratko (author)
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(creator_code:org_t)
- European Respiratory Society, 2018
- 2018
- English.
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In: European Respiratory Journal. - : European Respiratory Society. - 0903-1936 .- 1399-3003. ; 52
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Molecular stratification of childhood asthma could enable targeted therapy.Aims: Unbiased analysis of gene expression in paediatric severe (SA) and moderate/mild asthma (MA) blood samples to identify sub-phenotypes.Methods: Transcriptomic profiling by microarray analysis of blood from the U-BIOPRED paediatric cohort (Fleming ERJ 2015), pre- and school-age children, (SApre, n=62; MApre, n=42; SAsc, n=75 and MAsc, n=37). Topological data analysis (TDA) was used for unbiased clustering.Results: Sub-phenotypes, P1, P2, P3 and P4 were identified and are highlighted in the TDA network in the figure and a heatmap of selected variables. P1 (38% of the cohort, median 11 yrs) was characterised by low expression of glucocorticoid receptor (GR) mRNA splice variant with a long 3’ UTR (q = 2.43E-17), but no significant difference in the expression of glucocorticoid receptor (GR) mRNA splice variant with a short 3’ UTR. In P1, COX2 expression was up (q = 1.89E-06) and IFN-γ was down (q = 5.61E-06), characteristics of a decreased steroid response.Conclusion: Unbiased analysis of U-BIOPRED paediatric peripheral blood gene expression identified a sub-phenotype, P1, with an inhibited steroid response. P1 is associated with low expression of a splice variant of GR with a long 3’ UTR.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
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- vet (subject category)
- art (subject category)
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- By the author/editor
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Schofield, James ...
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Bigler, Jeanette
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Boedigheimer, Mi ...
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Affleck, Karen
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Taylor, Adam
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Pavlidis, Stelio ...
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show more...
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Riley, John H.
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Strazzeri, Fabio
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Roberts, Graham
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Brandsma, Joost
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Bansal, Aruna
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Nicholas, Ben
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Xian, Yang
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Rowe, Anthony
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Corfield, Julie
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Wilson, Susan
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Ward, Jonathan
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Lutter, Rene
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Fleming, Louise
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Shaw, Dominick
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Per, Bakke
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Caruso, Massimo
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Dahlen, Sven-Eri ...
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Fowler, Stephen
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Hashimoto, Simon ...
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Horvath, Ildiko
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Howarth, Peter
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Krug, Norbert
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Montuschi, Paolo
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Sanak, Marek
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Sandström, Thoma ...
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Singer, Florian
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Sun, Kai
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Pandis, Ioannis
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Auffray, Charles
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de Meulder, Bert ...
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Lefaudeux, Diane
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Knowles, Richard
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Fitch, Neil
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Sousa, Ana
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Adcock, Ian
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Chung, Kian Fan
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Sterk, Peter
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Skipp, Paul
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Djukanovic, Ratk ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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European Respira ...
- By the university
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Umeå University
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Karolinska Institutet