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  • Alahmadi, Fahad (author)

Measures of adherence in patients with severe asthma prescribed systemic steroids in the U-BIOPRED cohort

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • European Respiratory Society,2018
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:umu-156009
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-156009URI
  • https://doi.org/10.1183/13993003.congress-2018.PA3992DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:140072172URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:vet swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Supplement: 62Meeting Abstract: PA3992
  • Introduction: Rates of sub-optimal adherence to medications in asthma range up to 70%; the impact in severe asthma is likely to be particularly high. We measured self-reported adherence in participants in the U-BIOPRED cohort prescribed daily prednisolone using the Medication Adherence Response Scale (MARS), and compared to measured urinary prednisolone and metabolites in order to determine: 1. the prevalence of suboptimal adherence by each method; 2. the ability of MARS to predict urinary steroid detection.Methods: Participants completed the MARS, and/or provided urine samples (analysed for prednisolone and metabolites by LCMS). The performance characteristics of the MARS predicting undetected urinary steroid were calculated in the subgroup having both tests.Results: 181 participants currently taking regular oral corticosteroids were included, 59% female, mean (SD) age 54(12)yrs, FEV1 64.7(20.4)% predicted. Sub-optimal adherence (MARS score < 4.5) was reported in 62 participants, and 76 did not have detectable urinary prednisolone or metabolites. Good adherence by both methods was detected in only 52 participants (34%, see table). There was no difference in daily prednisolone dose between detectable and undetectable metabolites groups (p=0.848).Conclusion: Low levels of adherence to treatment in severe asthma is a common problem, when measured either directly or self-reported. There was very poor agreement (48% concordance) between these two methods, and we suggest that, for now both approaches should be used.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Simpson, Andrew (author)
  • Gomez, Christina (author)
  • Wheelock, Craig (author)
  • Shaw, Dominick (author)
  • Fleming, Louise (author)
  • Roberts, Graham (author)
  • Riley, John (author)
  • Bates, Stewart (author)
  • Sousa, Ana R. (author)
  • Knowles, Richard (author)
  • Bansal, Aruna (author)
  • Corfield, Julie (author)
  • Pandis, Ioannis (author)
  • Sun, Kai (author)
  • Bakke, Per (author)
  • Caruso, Massimo (author)
  • Chanez, Pascal (author)
  • Dahlen, Babro (author)
  • Horvath, Ildiko (author)
  • Krug, Norbert (author)
  • Montuschi, Paolo (author)
  • Sandström, Thomas,1957-Umeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)thsa0001 (author)
  • Singer, Florian (author)
  • Wagers, Scott (author)
  • Adcock, Ian (author)
  • Djukanovic, Ratko (author)
  • Chung, Kian (author)
  • Sterk, Peter J. (author)
  • Dahlen, Sven-Erik (author)
  • Fowler, Stephen J. (author)
  • Umeå universitetInstitutionen för folkhälsa och klinisk medicin (creator_code:org_t)

Related titles

  • In:European Respiratory Journal: European Respiratory Society520903-19361399-3003

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