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Different neuroinfl...
Different neuroinflammatory profile in amyotrophic lateral sclerosis and frontotemporal dementia is linked to the clinical phase
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Oeckl, Patrick (author)
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Weydt, Patrick (author)
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Steinacker, Petra (author)
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Anderl-Straub, Sarah (author)
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- Nordin, Frida (author)
- Umeå universitet,Klinisk neurovetenskap
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Volk, Alexander E. (author)
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Diehl-Schmid, Janine (author)
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- Andersen, Peter M., 1962- (author)
- Umeå universitet,Klinisk neurovetenskap,Department of Neurology, Ulm University hospital, Ulm, Germany
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Kornhuber, Johannes (author)
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Danek, Adrian (author)
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Fassbender, Klaus (author)
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Fliessbach, Klaus (author)
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Jahn, Holger (author)
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Lauer, Martin (author)
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Mueller, Kathrin (author)
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Knehr, Antje (author)
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Prudlo, Johannes (author)
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Schneider, Anja (author)
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Thal, Dietmar R. (author)
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Yilmazer-Hanke, Deniz (author)
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Weishaupt, Jochen H. (author)
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Ludolph, Albert C. (author)
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Otto, Markus (author)
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(creator_code:org_t)
- 2018-09-17
- 2019
- English.
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In: Journal of Neurology, Neurosurgery and Psychiatry. - : BMJ Publishing Group Ltd. - 0022-3050 .- 1468-330X. ; 90:1, s. 4-10
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objective: To investigate the role of neuroinflammation in asymptomatic and symptomatic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) mutation carriers.Methods: The neuroinflammatory markers chitotriosidase 1 (CHIT1), YKL-40 and glial fibrillary acidic protein (GFAP) were measured in cerebrospinal fluid (CSF) and blood samples from asymptomatic and symptomatic ALS/FTD mutation carriers, sporadic cases and controls by ELISA.Results: CSF levels of CHIT1, YKL-40 and GFAP were unaffected in asymptomatic mutation carriers (n=16). CHIT1 and YKL-40 were increased in gALS (p<0.001, n=65) whereas GFAP was not affected. Patients with ALS carrying a CHIT1 polymorphism had lower CHIT1 concentrations in CSF (-80%) whereas this polymorphism had no influence on disease severity. In gFTD (n=23), increased YKL-40 and GFAP were observed (p<0.05), whereas CHIT1 was nearly not affected. The same profile as in gALS and gFTD was observed in sALS (n=64/70) and sFTD (n=20/26). CSF and blood concentrations correlated moderately (CHIT1, r=0.51) to weak (YKL-40, r=0.30, GFAP, r=0.39). Blood concentrations of these three markers were not significantly altered in any of the groups except CHIT1 in gALS of the Ulm cohort (p<0.05).Conclusion: Our data indicate that neuroinflammation is linked to the symptomatic phase of ALS/FTD and shows a similar pattern in sporadic and genetic cases. ALS and FTD are characterised by a different neuroinflammatory profile, which might be one driver of the diverse presentations of the ALS/FTD syndrome.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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- art (subject category)
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Oeckl, Patrick
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Weydt, Patrick
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Steinacker, Petr ...
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Anderl-Straub, S ...
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Nordin, Frida
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Volk, Alexander ...
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Diehl-Schmid, Ja ...
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Andersen, Peter ...
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Kornhuber, Johan ...
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Danek, Adrian
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Fassbender, Klau ...
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Fliessbach, Klau ...
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Jahn, Holger
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Lauer, Martin
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Mueller, Kathrin
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Knehr, Antje
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Prudlo, Johannes
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Schneider, Anja
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Thal, Dietmar R.
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Yilmazer-Hanke, ...
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Weishaupt, Joche ...
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Ludolph, Albert ...
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Otto, Markus
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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Journal of Neuro ...
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Umeå University